Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.

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Bibliographic Details
Main Authors: Kelvin Chan, Jacquelyn Nestor, Tomás S. Huerta, Noele Certain, Gabrielle Moody, Czeslawa Kowal, Patricio T. Huerta, Bruce T. Volpe, Betty Diamond, Lonnie P. Wollmuth
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a5
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Summary:Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.

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