Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.

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Autores principales:	Kelvin Chan, Jacquelyn Nestor, Tomás S. Huerta, Noele Certain, Gabrielle Moody, Czeslawa Kowal, Patricio T. Huerta, Bruce T. Volpe, Betty Diamond, Lonnie P. Wollmuth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a5
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spelling	oai:doaj.org-article:a8fc9079fa874a23beb127b18897c7a52021-12-02T14:41:15ZLupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory10.1038/s41467-020-15224-w2041-1723https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a52020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15224-whttps://doaj.org/toc/2041-1723Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.Kelvin ChanJacquelyn NestorTomás S. HuertaNoele CertainGabrielle MoodyCzeslawa KowalPatricio T. HuertaBruce T. VolpeBetty DiamondLonnie P. WollmuthNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kelvin Chan Jacquelyn Nestor Tomás S. Huerta Noele Certain Gabrielle Moody Czeslawa Kowal Patricio T. Huerta Bruce T. Volpe Betty Diamond Lonnie P. Wollmuth Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
description	Systemic lupus erythematosus (SLE) is an autoimmune disorder which can have neurological manifestations, including autoantibody targeting of the NMDA receptor. In this study, the authors GluN2A subunit is a target of SLE autoantibodies, using sample derived from patient.
format	article
author	Kelvin Chan Jacquelyn Nestor Tomás S. Huerta Noele Certain Gabrielle Moody Czeslawa Kowal Patricio T. Huerta Bruce T. Volpe Betty Diamond Lonnie P. Wollmuth
author_facet	Kelvin Chan Jacquelyn Nestor Tomás S. Huerta Noele Certain Gabrielle Moody Czeslawa Kowal Patricio T. Huerta Bruce T. Volpe Betty Diamond Lonnie P. Wollmuth
author_sort	Kelvin Chan
title	Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
title_short	Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
title_full	Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
title_fullStr	Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
title_full_unstemmed	Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
title_sort	lupus autoantibodies act as positive allosteric modulators at glun2a-containing nmda receptors and impair spatial memory
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a8fc9079fa874a23beb127b18897c7a5
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Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory

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