The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study
Abstract Background The effect of comorbid hypertriglyceridemia (HTG) and abdominal obesity (AO) on acute pancreatitis (AP) remains unclear. The aim of this study was to explore the effect of comorbid HTG and AO and discuss which is the dominant disorder. Methods In this study, 1219 AP patients who...
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2021
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oai:doaj.org-article:a8fd1259c53f4e3eb94b1e03fe1770682021-11-28T12:39:01ZThe role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study10.1186/s12944-021-01597-41476-511Xhttps://doaj.org/article/a8fd1259c53f4e3eb94b1e03fe1770682021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01597-4https://doaj.org/toc/1476-511XAbstract Background The effect of comorbid hypertriglyceridemia (HTG) and abdominal obesity (AO) on acute pancreatitis (AP) remains unclear. The aim of this study was to explore the effect of comorbid HTG and AO and discuss which is the dominant disorder. Methods In this study, 1219 AP patients who presented with HTG or AO were stratified into four groups: non-HTG + non-AO, HTG + non-AO, non-HTG + AO, and HTG + AO. Results The 328 patients with comorbid HTG + AO were much younger (42.29 ± 11.77), mainly male (79.57%), and had higher TG levels, larger waist circumferences, and more past medical histories than the patients in the other three non-comorbid groups (P < 0.001). The comorbidity group developed more incidences of persistent organ failure and local complications (P < 0.05). Multivariate logistic regression analysis showed that AO (OR = 3.205, 95% CI = 1.570–6.544), mild HTG (OR = 2.746, 95% CI = 1.125–6.701), and moderate to very severe HTG (OR = 3.649, 95% CI = 1.403–9.493) were independent risk factors for persistent respiratory failure (P < 0.05). Age > 60 years (OR = 1.326, 95% CI = 1.047–1.679), AO (OR = 1.701, 95% CI = 1.308–2.212), diabetes mellitus (OR = 1.551, 95% CI = 1.063–2.261), mild HTG (OR = 1.549, 95% CI = 1.137–2.112), and moderate to very severe HTG (OR = 2.810, 95% CI = 1.926–4.100) were independent risk factors associated with local complications (P < 0.05). Moreover, HTG seemed to be more dangerous than AO. The higher the serum TG level was, the greater the likelihood of persistent respiratory failure and local complications. Conclusions Comorbid HTG and AO will aggravate the severity and increase the incidence of local complications of AP. HTG may play a dominant role of risk in the condition of comorbidity. Chinese clinical trial registry ChiCTR2100049566 . Registered on 3rd August, 2021. Retrospectively registered, https://www.chictr.org.cn/edit.aspx?pid=127374&htm=4 .Xiaoxi YangJiajun HeShuli MaTingting WangQuping ZhuFei CaoYuanhao LiChuting YangChaowu ChenGuotao LuLianghao HuJun LiuWeiwei ChenBMCarticleHypertriglyceridemiaAbdominal obesityAcute pancreatitisNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-8 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Hypertriglyceridemia Abdominal obesity Acute pancreatitis Nutritional diseases. Deficiency diseases RC620-627 |
| spellingShingle |
Hypertriglyceridemia Abdominal obesity Acute pancreatitis Nutritional diseases. Deficiency diseases RC620-627 Xiaoxi Yang Jiajun He Shuli Ma Tingting Wang Quping Zhu Fei Cao Yuanhao Li Chuting Yang Chaowu Chen Guotao Lu Lianghao Hu Jun Liu Weiwei Chen The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| description |
Abstract Background The effect of comorbid hypertriglyceridemia (HTG) and abdominal obesity (AO) on acute pancreatitis (AP) remains unclear. The aim of this study was to explore the effect of comorbid HTG and AO and discuss which is the dominant disorder. Methods In this study, 1219 AP patients who presented with HTG or AO were stratified into four groups: non-HTG + non-AO, HTG + non-AO, non-HTG + AO, and HTG + AO. Results The 328 patients with comorbid HTG + AO were much younger (42.29 ± 11.77), mainly male (79.57%), and had higher TG levels, larger waist circumferences, and more past medical histories than the patients in the other three non-comorbid groups (P < 0.001). The comorbidity group developed more incidences of persistent organ failure and local complications (P < 0.05). Multivariate logistic regression analysis showed that AO (OR = 3.205, 95% CI = 1.570–6.544), mild HTG (OR = 2.746, 95% CI = 1.125–6.701), and moderate to very severe HTG (OR = 3.649, 95% CI = 1.403–9.493) were independent risk factors for persistent respiratory failure (P < 0.05). Age > 60 years (OR = 1.326, 95% CI = 1.047–1.679), AO (OR = 1.701, 95% CI = 1.308–2.212), diabetes mellitus (OR = 1.551, 95% CI = 1.063–2.261), mild HTG (OR = 1.549, 95% CI = 1.137–2.112), and moderate to very severe HTG (OR = 2.810, 95% CI = 1.926–4.100) were independent risk factors associated with local complications (P < 0.05). Moreover, HTG seemed to be more dangerous than AO. The higher the serum TG level was, the greater the likelihood of persistent respiratory failure and local complications. Conclusions Comorbid HTG and AO will aggravate the severity and increase the incidence of local complications of AP. HTG may play a dominant role of risk in the condition of comorbidity. Chinese clinical trial registry ChiCTR2100049566 . Registered on 3rd August, 2021. Retrospectively registered, https://www.chictr.org.cn/edit.aspx?pid=127374&htm=4 . |
| format |
article |
| author |
Xiaoxi Yang Jiajun He Shuli Ma Tingting Wang Quping Zhu Fei Cao Yuanhao Li Chuting Yang Chaowu Chen Guotao Lu Lianghao Hu Jun Liu Weiwei Chen |
| author_facet |
Xiaoxi Yang Jiajun He Shuli Ma Tingting Wang Quping Zhu Fei Cao Yuanhao Li Chuting Yang Chaowu Chen Guotao Lu Lianghao Hu Jun Liu Weiwei Chen |
| author_sort |
Xiaoxi Yang |
| title |
The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| title_short |
The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| title_full |
The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| title_fullStr |
The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| title_full_unstemmed |
The role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| title_sort |
role of comorbid hypertriglyceridemia and abdominal obesity in the severity of acute pancreatitis: a retrospective study |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/a8fd1259c53f4e3eb94b1e03fe177068 |
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