No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.

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Autores principales:	Albertas Navickas, Sébastien Chamois, Rénette Saint-Fort, Julien Henri, Claire Torchet, Lionel Benard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a8fd17d189c847329043a5bf30ab1d19
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spelling	oai:doaj.org-article:a8fd17d189c847329043a5bf30ab1d192021-12-02T14:42:14ZNo-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl110.1038/s41467-019-13991-92041-1723https://doaj.org/article/a8fd17d189c847329043a5bf30ab1d192020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13991-9https://doaj.org/toc/2041-1723In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.Albertas NavickasSébastien ChamoisRénette Saint-FortJulien HenriClaire TorchetLionel BenardNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
description	In the No-Go decay mRNA surveillance pathway, mRNAs containing stalled ribosomes are cleaved by an endoribonuclease. Here the authors show the endonucleolytic cleavage on the artificial No-Go decay target mRNAs, revealing downstream decay process by Trl1 kinase and the 5′ to 3′ exonuclease Dxo1.
format	article
author	Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard
author_facet	Albertas Navickas Sébastien Chamois Rénette Saint-Fort Julien Henri Claire Torchet Lionel Benard
author_sort	Albertas Navickas
title	No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
title_short	No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
title_full	No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
title_fullStr	No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
title_full_unstemmed	No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1
title_sort	no-go decay mrna cleavage in the ribosome exit tunnel produces 5′-oh ends phosphorylated by trl1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a8fd17d189c847329043a5bf30ab1d19
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No-Go Decay mRNA cleavage in the ribosome exit tunnel produces 5′-OH ends phosphorylated by Trl1

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