High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites

Chinmaya Mutalik,1,* Yu-Cheng Hsiao,1,2,* Yi-Hsuan Chang,3 Dyah Ika Krisnawati,4 Moh Alimansur,4 Achmad Jazidie,5,6 Mohammad Nuh,7 Chia-Che Chang,8 Di-Yan Wang,8 Tsung-Rong Kuo1,3 1International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taip...

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Autores principales:	Mutalik C, Hsiao YC, Chang YH, Krisnawati DI, Alimansur M, Jazidie A, Nuh M, Chang CC, Wang DY, Kuo TR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	antibacterial agent antibacterial mechanism reactive oxygen species light harvester light-induced antibacterial activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a9024b56d57a49e6b6ec769d9954985a
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spelling	oai:doaj.org-article:a9024b56d57a49e6b6ec769d9954985a2021-12-02T15:05:53ZHigh UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites1178-2013https://doaj.org/article/a9024b56d57a49e6b6ec769d9954985a2020-11-01T00:00:00Zhttps://www.dovepress.com/high-uv-vis-nir-light-induced-antibacterial-activity-by-heterostructur-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chinmaya Mutalik,1,* Yu-Cheng Hsiao,1,2,* Yi-Hsuan Chang,3 Dyah Ika Krisnawati,4 Moh Alimansur,4 Achmad Jazidie,5,6 Mohammad Nuh,7 Chia-Che Chang,8 Di-Yan Wang,8 Tsung-Rong Kuo1,3 1International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 2Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 3Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 4Dharma Husada Nursing Academy, Kediri, East Java 64114, Indonesia; 5Department of Electrical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia; 6Universitas Nahdlatul Ulama Surabaya, Surabaya 60111, Indonesia; 7Department of Biomedical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia; 8Department of Chemistry, Tunghai University, Taichung 40704, Taiwan*These authors contributed equally to this workCorrespondence: Di-Yan WangDepartment of Chemistry, Tunghai University, Taichung 40704, TaiwanTel +886-4-23590121Email diyanwang@thu.edu.twTsung-Rong KuoGraduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, TaiwanTel +886-2-27361661Email trkuo@tmu.edu.twPurpose: Antibiotic resistance issues associated with microbial pathogenesis are considered to be one of the most serious current threats to health. Fortunately, TiO2, a photoactive semiconductor, was proven to have antibacterial activity and is being widely utilized. However, its use is limited to the short range of absorption wavelength.Methods: In this work, heterostructured TiO2-FeS2 nanocomposites (NCs) were successfully prepared by a facile solution approach to enhance light-induced antibacterial activity over a broader absorption range.Results: In TiO2-FeS2 NCs, FeS2 NPs, as light harvesters, can effectively increase light absorption from the visible (Vis) to near-infrared (NIR). Results of light-induced antibacterial activities indicated that TiO2-FeS2 NCs had better antibacterial activity than that of only TiO2 nanoparticles (NPs) or only FeS2 NPs. Reactive oxygen species (ROS) measurements also showed that TiO2-FeS2 NCs produced the highest relative ROS levels. Unlike TiO2 NPs, TiO2-FeS2 NCs, under light irradiation with a 515-nm filter, could absorb light wavelengths longer than 515 nm to generate ROS. In the mechanistic study, we found that TiO2 NPs in TiO2-FeS2 NCs could absorb ultraviolet (UV) light to generate photoinduced electrons and holes for ROS generation, including ⋅O2− and ⋅OH; FeS2 NPs efficiently harvested Vis to NIR light to generate photoinduced electrons, which then were transferred to TiO2 NPs to facilitate ROS generation.Conclusion: TiO2-FeS2 NCs with superior light-induced antibacterial activity could be a promising antibacterial agent against bacterial infections.Keywords: antibacterial agent, antibacterial mechanism, reactive oxygen species, light harvester, light-induced antibacterial activityMutalik CHsiao YCChang YHKrisnawati DIAlimansur MJazidie ANuh MChang CCWang DYKuo TRDove Medical Pressarticleantibacterial agentantibacterial mechanismreactive oxygen specieslight harvesterlight-induced antibacterial activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8911-8920 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibacterial agent antibacterial mechanism reactive oxygen species light harvester light-induced antibacterial activity Medicine (General) R5-920
spellingShingle	antibacterial agent antibacterial mechanism reactive oxygen species light harvester light-induced antibacterial activity Medicine (General) R5-920 Mutalik C Hsiao YC Chang YH Krisnawati DI Alimansur M Jazidie A Nuh M Chang CC Wang DY Kuo TR High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
description	Chinmaya Mutalik,1,* Yu-Cheng Hsiao,1,2,* Yi-Hsuan Chang,3 Dyah Ika Krisnawati,4 Moh Alimansur,4 Achmad Jazidie,5,6 Mohammad Nuh,7 Chia-Che Chang,8 Di-Yan Wang,8 Tsung-Rong Kuo1,3 1International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 2Graduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 3Graduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan; 4Dharma Husada Nursing Academy, Kediri, East Java 64114, Indonesia; 5Department of Electrical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia; 6Universitas Nahdlatul Ulama Surabaya, Surabaya 60111, Indonesia; 7Department of Biomedical Engineering, Institut Teknologi Sepuluh Nopember, Surabaya 60111, Indonesia; 8Department of Chemistry, Tunghai University, Taichung 40704, Taiwan*These authors contributed equally to this workCorrespondence: Di-Yan WangDepartment of Chemistry, Tunghai University, Taichung 40704, TaiwanTel +886-4-23590121Email diyanwang@thu.edu.twTsung-Rong KuoGraduate Institute of Nanomedicine and Medical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, TaiwanTel +886-2-27361661Email trkuo@tmu.edu.twPurpose: Antibiotic resistance issues associated with microbial pathogenesis are considered to be one of the most serious current threats to health. Fortunately, TiO2, a photoactive semiconductor, was proven to have antibacterial activity and is being widely utilized. However, its use is limited to the short range of absorption wavelength.Methods: In this work, heterostructured TiO2-FeS2 nanocomposites (NCs) were successfully prepared by a facile solution approach to enhance light-induced antibacterial activity over a broader absorption range.Results: In TiO2-FeS2 NCs, FeS2 NPs, as light harvesters, can effectively increase light absorption from the visible (Vis) to near-infrared (NIR). Results of light-induced antibacterial activities indicated that TiO2-FeS2 NCs had better antibacterial activity than that of only TiO2 nanoparticles (NPs) or only FeS2 NPs. Reactive oxygen species (ROS) measurements also showed that TiO2-FeS2 NCs produced the highest relative ROS levels. Unlike TiO2 NPs, TiO2-FeS2 NCs, under light irradiation with a 515-nm filter, could absorb light wavelengths longer than 515 nm to generate ROS. In the mechanistic study, we found that TiO2 NPs in TiO2-FeS2 NCs could absorb ultraviolet (UV) light to generate photoinduced electrons and holes for ROS generation, including ⋅O2− and ⋅OH; FeS2 NPs efficiently harvested Vis to NIR light to generate photoinduced electrons, which then were transferred to TiO2 NPs to facilitate ROS generation.Conclusion: TiO2-FeS2 NCs with superior light-induced antibacterial activity could be a promising antibacterial agent against bacterial infections.Keywords: antibacterial agent, antibacterial mechanism, reactive oxygen species, light harvester, light-induced antibacterial activity
format	article
author	Mutalik C Hsiao YC Chang YH Krisnawati DI Alimansur M Jazidie A Nuh M Chang CC Wang DY Kuo TR
author_facet	Mutalik C Hsiao YC Chang YH Krisnawati DI Alimansur M Jazidie A Nuh M Chang CC Wang DY Kuo TR
author_sort	Mutalik C
title	High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
title_short	High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
title_full	High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
title_fullStr	High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
title_full_unstemmed	High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites
title_sort	high uv-vis-nir light-induced antibacterial activity by heterostructured tio2-fes2 nanocomposites
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/a9024b56d57a49e6b6ec769d9954985a
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High UV-Vis-NIR Light-Induced Antibacterial Activity by Heterostructured TiO2-FeS2 Nanocomposites

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