Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction

The success of extinction learning is not predictive of long-term retrieval of an extinction memory. Using fMRI to study consolidation of fear extinction in human subjects, the authors show that reactivation in the ventromedial prefrontal cortex during memory retrieval predicts extinction memory ret...

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Autores principales:	A. M. V. Gerlicher, O. Tüscher, R. Kalisch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9037a38fab64222a84815886e10070c
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id	oai:doaj.org-article:a9037a38fab64222a84815886e10070c
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spelling	oai:doaj.org-article:a9037a38fab64222a84815886e10070c2021-12-02T17:32:34ZDopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction10.1038/s41467-018-06785-y2041-1723https://doaj.org/article/a9037a38fab64222a84815886e10070c2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06785-yhttps://doaj.org/toc/2041-1723The success of extinction learning is not predictive of long-term retrieval of an extinction memory. Using fMRI to study consolidation of fear extinction in human subjects, the authors show that reactivation in the ventromedial prefrontal cortex during memory retrieval predicts extinction memory retrieval, and that increasing dopaminergic signaling increases the number of these activations.A. M. V. GerlicherO. TüscherR. KalischNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q A. M. V. Gerlicher O. Tüscher R. Kalisch Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
description	The success of extinction learning is not predictive of long-term retrieval of an extinction memory. Using fMRI to study consolidation of fear extinction in human subjects, the authors show that reactivation in the ventromedial prefrontal cortex during memory retrieval predicts extinction memory retrieval, and that increasing dopaminergic signaling increases the number of these activations.
format	article
author	A. M. V. Gerlicher O. Tüscher R. Kalisch
author_facet	A. M. V. Gerlicher O. Tüscher R. Kalisch
author_sort	A. M. V. Gerlicher
title	Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
title_short	Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
title_full	Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
title_fullStr	Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
title_full_unstemmed	Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
title_sort	dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a9037a38fab64222a84815886e10070c
work_keys_str_mv	AT amvgerlicher dopaminedependentprefrontalreactivationsexplainlongtermbenefitoffearextinction AT otuscher dopaminedependentprefrontalreactivationsexplainlongtermbenefitoffearextinction AT rkalisch dopaminedependentprefrontalreactivationsexplainlongtermbenefitoffearextinction
_version_	1718380268017942528

Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction

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