Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target
Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-STAT pathway, revealing potential ANKL therapeutic...
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Nature Portfolio
2018
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oai:doaj.org-article:a90516e221ea4f0c9791e1e130cc3ead2021-12-02T16:49:48ZAggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target10.1038/s41467-018-03987-22041-1723https://doaj.org/article/a90516e221ea4f0c9791e1e130cc3ead2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03987-2https://doaj.org/toc/2041-1723Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-STAT pathway, revealing potential ANKL therapeutic targets.Olli DufvaMatti KankainenTiina KelkkaNodoka SekiguchiShady Adnan AwadSamuli EldforsBhagwan YadavHeikki KuusanmäkiDisha MalaniEmma I AnderssonPaavo PietarinenLeena SaikkoPanu E. KovanenTeija OjalaDean A. LeeThomas P. LoughranHideyuki NakazawaJunji SuzumiyaRitsuro SuzukiYoung Hyeh KoWon Seog KimShih-Sung ChuangTero AittokallioWing C. ChanKoichi OhshimaFumihiro IshidaSatu MustjokiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Olli Dufva Matti Kankainen Tiina Kelkka Nodoka Sekiguchi Shady Adnan Awad Samuli Eldfors Bhagwan Yadav Heikki Kuusanmäki Disha Malani Emma I Andersson Paavo Pietarinen Leena Saikko Panu E. Kovanen Teija Ojala Dean A. Lee Thomas P. Loughran Hideyuki Nakazawa Junji Suzumiya Ritsuro Suzuki Young Hyeh Ko Won Seog Kim Shih-Sung Chuang Tero Aittokallio Wing C. Chan Koichi Ohshima Fumihiro Ishida Satu Mustjoki Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| description |
Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-STAT pathway, revealing potential ANKL therapeutic targets. |
| format |
article |
| author |
Olli Dufva Matti Kankainen Tiina Kelkka Nodoka Sekiguchi Shady Adnan Awad Samuli Eldfors Bhagwan Yadav Heikki Kuusanmäki Disha Malani Emma I Andersson Paavo Pietarinen Leena Saikko Panu E. Kovanen Teija Ojala Dean A. Lee Thomas P. Loughran Hideyuki Nakazawa Junji Suzumiya Ritsuro Suzuki Young Hyeh Ko Won Seog Kim Shih-Sung Chuang Tero Aittokallio Wing C. Chan Koichi Ohshima Fumihiro Ishida Satu Mustjoki |
| author_facet |
Olli Dufva Matti Kankainen Tiina Kelkka Nodoka Sekiguchi Shady Adnan Awad Samuli Eldfors Bhagwan Yadav Heikki Kuusanmäki Disha Malani Emma I Andersson Paavo Pietarinen Leena Saikko Panu E. Kovanen Teija Ojala Dean A. Lee Thomas P. Loughran Hideyuki Nakazawa Junji Suzumiya Ritsuro Suzuki Young Hyeh Ko Won Seog Kim Shih-Sung Chuang Tero Aittokallio Wing C. Chan Koichi Ohshima Fumihiro Ishida Satu Mustjoki |
| author_sort |
Olli Dufva |
| title |
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| title_short |
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| title_full |
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| title_fullStr |
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| title_full_unstemmed |
Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target |
| title_sort |
aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight jak-stat signaling as therapeutic target |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a90516e221ea4f0c9791e1e130cc3ead |
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