Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers

Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological processes. Dysregulation of these processes me...

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Autores principales:	Lin Zhou, Taohui Ouyang, Meihua Li, Tao Hong, Alriashy MHS, Wei Meng, Na Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ubiquitin-specific peptidase 7 deubiquitinase cancer neoplasms protein homeostasis proteostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a9051f2a9d2c493185f9feb244e241bc
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spelling	oai:doaj.org-article:a9051f2a9d2c493185f9feb244e241bc2021-11-19T06:02:38ZUbiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers2234-943X10.3389/fonc.2021.784672https://doaj.org/article/a9051f2a9d2c493185f9feb244e241bc2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.784672/fullhttps://doaj.org/toc/2234-943XUbiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological processes. Dysregulation of these processes mediated by USP7 may contribute to many diseases, such as cancers. Moreover, USP7 with aberrant expression levels and abnormal activity are found in cancers. Therefore, given the association between USP7 and cancers, targeting USP7 could be considered as an attractive and potential therapeutic approach in cancer treatment. This review describes the functions of USP7 and the regulatory mechanisms of its expression and activity, aiming to emphasize the necessity of research on USP7, and provide a better understanding of USP7-related biological processes and cancer.Lin ZhouTaohui OuyangMeihua LiTao HongAlriashy MHSWei MengNa ZhangFrontiers Media S.A.articleubiquitin-specific peptidase 7deubiquitinasecancerneoplasmsprotein homeostasisproteostasisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ubiquitin-specific peptidase 7 deubiquitinase cancer neoplasms protein homeostasis proteostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ubiquitin-specific peptidase 7 deubiquitinase cancer neoplasms protein homeostasis proteostasis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lin Zhou Taohui Ouyang Meihua Li Tao Hong Alriashy MHS Wei Meng Na Zhang Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
description	Ubiquitin-Specific Peptidase 7 (USP7), or herpes virus-associated protease (HAUSP), is the largest family of the deubiquitinating enzymes (DUBs). Recent studies have shown that USP7 plays a vital role in regulating various physiological and pathological processes. Dysregulation of these processes mediated by USP7 may contribute to many diseases, such as cancers. Moreover, USP7 with aberrant expression levels and abnormal activity are found in cancers. Therefore, given the association between USP7 and cancers, targeting USP7 could be considered as an attractive and potential therapeutic approach in cancer treatment. This review describes the functions of USP7 and the regulatory mechanisms of its expression and activity, aiming to emphasize the necessity of research on USP7, and provide a better understanding of USP7-related biological processes and cancer.
format	article
author	Lin Zhou Taohui Ouyang Meihua Li Tao Hong Alriashy MHS Wei Meng Na Zhang
author_facet	Lin Zhou Taohui Ouyang Meihua Li Tao Hong Alriashy MHS Wei Meng Na Zhang
author_sort	Lin Zhou
title	Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
title_short	Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
title_full	Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
title_fullStr	Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
title_full_unstemmed	Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers
title_sort	ubiquitin-specific peptidase 7: a novel deubiquitinase that regulates protein homeostasis and cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a9051f2a9d2c493185f9feb244e241bc
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Ubiquitin-Specific Peptidase 7: A Novel Deubiquitinase That Regulates Protein Homeostasis and Cancers

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