Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers

Hui Yang,* Lan Liu,* Gai Li, Yinchen Chen, Dong Jiang, Wei Wang, Tianyuan Wang, Jinshan Sun, Jianfang Che, Dongmei Gu, Meng Lu, Aiping Wang Department of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, Nanjing 210029, People’s Republic of China*These authors contributed...

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Autores principales:	Yang H, Liu L, Li G, Chen Y, Jiang D, Wang W, Wang T, Sun J, Che J, Gu D, Lu M, Wang A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	vacuum sealing drainage，diabetic foot ulcers，wound healing cd34 cd68 vegf Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a90fea87a10e4c43b87f47d2759eae83
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spelling	oai:doaj.org-article:a90fea87a10e4c43b87f47d2759eae832021-12-02T10:57:13ZGrowth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers1178-203Xhttps://doaj.org/article/a90fea87a10e4c43b87f47d2759eae832021-01-01T00:00:00Zhttps://www.dovepress.com/growth-promoting-effect-of-vacuum-sealing-drainage-in-the-healing-proc-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XHui Yang,* Lan Liu,* Gai Li, Yinchen Chen, Dong Jiang, Wei Wang, Tianyuan Wang, Jinshan Sun, Jianfang Che, Dongmei Gu, Meng Lu, Aiping Wang Department of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, Nanjing 210029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Aiping Wang; Meng LuDepartment of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, 1 Malujie Road, Nanjing 210029, People’s Republic of ChinaTel +86-25-80865162Email wap454hospital@163.com; lumeng365@hotmail.comAim: To explore the growth-promoting effect of vacuum sealing drainage (VSD) during the healing processes of diabetic foot ulcers (DFUs).Methods: From November 2018 to December 2019, 38 patients with unilateral DFUs were enrolled in this retrospective study. All patients were divided into two groups according to the use of VSD or not: the VSD group (n=20) and the control group (n=18). The following parameters were used to evaluate the healing process: changes in the mean areas of the ulcers; healing rate (HR); epithelial hyperplasia and angiogenesis as determined by hematoxylin-eosin staining (HE staining); and expression of CD34, CD68 and VEGF as assessed through immunohistochemistry. Perioperative side effects and complications were also recorded.Results: All patients received follow-up and eventually healed. The mean area of wounds was reduced in the VSD group compared to the control group (1.75± 0.64 cm2 vs 0.88± 0.54 cm2, P=0.031). The mean HR of the ulcers in the VSD group was significantly higher than that in the control group (35.23± 2.87% vs 28.78± 1.09%, P=0.017). HE staining showed that the amount of epithelial hyperplasia and angiogenesis increased significantly after VSD, and the immunohistochemistry results showed that the expression of CD34, CD68 and VEGF increased significantly in the VSD group.Conclusion: VSD could significantly accelerate the wound healing process, probably by enhancing the inflammatory response and promoting granulation and angiogenesis in DFUs.Keywords: vacuum sealing drainage, diabetic foot ulcers, wound healing, CD34, CD68, VEGFYang HLiu LLi GChen YJiang DWang WWang TSun JChe JGu DLu MWang ADove Medical Pressarticlevacuum sealing drainage，diabetic foot ulcers，wound healingcd34cd68vegfTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 17, Pp 65-71 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vacuum sealing drainage，diabetic foot ulcers，wound healing cd34 cd68 vegf Therapeutics. Pharmacology RM1-950
spellingShingle	vacuum sealing drainage，diabetic foot ulcers，wound healing cd34 cd68 vegf Therapeutics. Pharmacology RM1-950 Yang H Liu L Li G Chen Y Jiang D Wang W Wang T Sun J Che J Gu D Lu M Wang A Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
description	Hui Yang,* Lan Liu,* Gai Li, Yinchen Chen, Dong Jiang, Wei Wang, Tianyuan Wang, Jinshan Sun, Jianfang Che, Dongmei Gu, Meng Lu, Aiping Wang Department of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, Nanjing 210029, People’s Republic of China*These authors contributed equally to this workCorrespondence: Aiping Wang; Meng LuDepartment of Endocrinology, The Air Force Hospital from Eastern Theater of PLA, 1 Malujie Road, Nanjing 210029, People’s Republic of ChinaTel +86-25-80865162Email wap454hospital@163.com; lumeng365@hotmail.comAim: To explore the growth-promoting effect of vacuum sealing drainage (VSD) during the healing processes of diabetic foot ulcers (DFUs).Methods: From November 2018 to December 2019, 38 patients with unilateral DFUs were enrolled in this retrospective study. All patients were divided into two groups according to the use of VSD or not: the VSD group (n=20) and the control group (n=18). The following parameters were used to evaluate the healing process: changes in the mean areas of the ulcers; healing rate (HR); epithelial hyperplasia and angiogenesis as determined by hematoxylin-eosin staining (HE staining); and expression of CD34, CD68 and VEGF as assessed through immunohistochemistry. Perioperative side effects and complications were also recorded.Results: All patients received follow-up and eventually healed. The mean area of wounds was reduced in the VSD group compared to the control group (1.75± 0.64 cm2 vs 0.88± 0.54 cm2, P=0.031). The mean HR of the ulcers in the VSD group was significantly higher than that in the control group (35.23± 2.87% vs 28.78± 1.09%, P=0.017). HE staining showed that the amount of epithelial hyperplasia and angiogenesis increased significantly after VSD, and the immunohistochemistry results showed that the expression of CD34, CD68 and VEGF increased significantly in the VSD group.Conclusion: VSD could significantly accelerate the wound healing process, probably by enhancing the inflammatory response and promoting granulation and angiogenesis in DFUs.Keywords: vacuum sealing drainage, diabetic foot ulcers, wound healing, CD34, CD68, VEGF
format	article
author	Yang H Liu L Li G Chen Y Jiang D Wang W Wang T Sun J Che J Gu D Lu M Wang A
author_facet	Yang H Liu L Li G Chen Y Jiang D Wang W Wang T Sun J Che J Gu D Lu M Wang A
author_sort	Yang H
title	Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
title_short	Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
title_full	Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
title_fullStr	Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
title_full_unstemmed	Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers
title_sort	growth promoting effect of vacuum sealing drainage in the healing processes of diabetic foot ulcers
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/a90fea87a10e4c43b87f47d2759eae83
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Growth Promoting Effect of Vacuum Sealing Drainage in the Healing Processes of Diabetic Foot Ulcers

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