Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States

Abstract Antibiotic resistance, particularly to fluoroquinolones and macrolides, in the major foodborne pathogen Campylobacter is considered a serious threat to public health. Although ruminant animals serve as a significant reservoir for Campylobacter, limited information is available on antibiotic...

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Autores principales:	Yizhi Tang, Orhan Sahin, Nada Pavlovic, Jeff LeJeune, James Carlson, Zuowei Wu, Lei Dai, Qijing Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a910915297e7441191374c44db5089a9
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spelling	oai:doaj.org-article:a910915297e7441191374c44db5089a92021-12-02T15:06:22ZRising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States10.1038/s41598-017-00584-z2045-2322https://doaj.org/article/a910915297e7441191374c44db5089a92017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00584-zhttps://doaj.org/toc/2045-2322Abstract Antibiotic resistance, particularly to fluoroquinolones and macrolides, in the major foodborne pathogen Campylobacter is considered a serious threat to public health. Although ruminant animals serve as a significant reservoir for Campylobacter, limited information is available on antibiotic-resistant Campylobacter of bovine origin. Here, we analyzed the antimicrobial susceptibilities of 320 C. jejuni and 115 C. coli isolates obtained from feedlot cattle farms in multiple states in the U.S. The results indicate that fluoroquinolone resistance reached to 35.4% in C. jejuni and 74.4% in C. coli, which are significantly higher than those previously reported in the U.S. While all fluoroquinolone resistant (FQR) C. coli isolates examined in this study harbored the single Thr-86-Ile mutation in GyrA, FQR C. jejuni isolates had other mutations in GyrA in addition to the Thr-86-Ile change. Notably, most of the analyzed FQR C. coli isolates had similar PFGE (pulsed field gel electrophoresis) patterns and the same MLST (multilocus sequence typing) sequence type (ST-1068) regardless of their geographic sources and time of isolation, while the analyzed C. jejuni isolates were genetically diverse, suggesting that clonal expansion is involved in dissemination of FQR C. coli but not C. jejuni. These findings reveal the rising prevalence of FQR Campylobacter in the U.S. and provide novel information on the epidemiology of antibiotic-resistant Campylobacter in the ruminant reservoir.Yizhi TangOrhan SahinNada PavlovicJeff LeJeuneJames CarlsonZuowei WuLei DaiQijing ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yizhi Tang Orhan Sahin Nada Pavlovic Jeff LeJeune James Carlson Zuowei Wu Lei Dai Qijing Zhang Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
description	Abstract Antibiotic resistance, particularly to fluoroquinolones and macrolides, in the major foodborne pathogen Campylobacter is considered a serious threat to public health. Although ruminant animals serve as a significant reservoir for Campylobacter, limited information is available on antibiotic-resistant Campylobacter of bovine origin. Here, we analyzed the antimicrobial susceptibilities of 320 C. jejuni and 115 C. coli isolates obtained from feedlot cattle farms in multiple states in the U.S. The results indicate that fluoroquinolone resistance reached to 35.4% in C. jejuni and 74.4% in C. coli, which are significantly higher than those previously reported in the U.S. While all fluoroquinolone resistant (FQR) C. coli isolates examined in this study harbored the single Thr-86-Ile mutation in GyrA, FQR C. jejuni isolates had other mutations in GyrA in addition to the Thr-86-Ile change. Notably, most of the analyzed FQR C. coli isolates had similar PFGE (pulsed field gel electrophoresis) patterns and the same MLST (multilocus sequence typing) sequence type (ST-1068) regardless of their geographic sources and time of isolation, while the analyzed C. jejuni isolates were genetically diverse, suggesting that clonal expansion is involved in dissemination of FQR C. coli but not C. jejuni. These findings reveal the rising prevalence of FQR Campylobacter in the U.S. and provide novel information on the epidemiology of antibiotic-resistant Campylobacter in the ruminant reservoir.
format	article
author	Yizhi Tang Orhan Sahin Nada Pavlovic Jeff LeJeune James Carlson Zuowei Wu Lei Dai Qijing Zhang
author_facet	Yizhi Tang Orhan Sahin Nada Pavlovic Jeff LeJeune James Carlson Zuowei Wu Lei Dai Qijing Zhang
author_sort	Yizhi Tang
title	Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
title_short	Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
title_full	Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
title_fullStr	Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
title_full_unstemmed	Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States
title_sort	rising fluoroquinolone resistance in campylobacter isolated from feedlot cattle in the united states
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a910915297e7441191374c44db5089a9
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Rising fluoroquinolone resistance in Campylobacter isolated from feedlot cattle in the United States

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