Microstructure abnormalities in adolescents with internet addiction disorder.

<h4>Background</h4>Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, a...

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Autores principales:	Kai Yuan, Wei Qin, Guihong Wang, Fang Zeng, Liyan Zhao, Xuejuan Yang, Peng Liu, Jixin Liu, Jinbo Sun, Karen M von Deneen, Qiyong Gong, Yijun Liu, Jie Tian
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a911b7c9e0c34dbe8ed2ac89954ca60a
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spelling	oai:doaj.org-article:a911b7c9e0c34dbe8ed2ac89954ca60a2021-11-18T06:52:37ZMicrostructure abnormalities in adolescents with internet addiction disorder.1932-620310.1371/journal.pone.0020708https://doaj.org/article/a911b7c9e0c34dbe8ed2ac89954ca60a2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21677775/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction.<h4>Methodology/principal findings</h4>We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD.<h4>Conclusions</h4>Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.Kai YuanWei QinGuihong WangFang ZengLiyan ZhaoXuejuan YangPeng LiuJixin LiuJinbo SunKaren M von DeneenQiyong GongYijun LiuJie TianPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20708 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kai Yuan Wei Qin Guihong Wang Fang Zeng Liyan Zhao Xuejuan Yang Peng Liu Jixin Liu Jinbo Sun Karen M von Deneen Qiyong Gong Yijun Liu Jie Tian Microstructure abnormalities in adolescents with internet addiction disorder.
description	<h4>Background</h4>Recent studies suggest that internet addiction disorder (IAD) is associated with structural abnormalities in brain gray matter. However, few studies have investigated the effects of internet addiction on the microstructural integrity of major neuronal fiber pathways, and almost no studies have assessed the microstructural changes with the duration of internet addiction.<h4>Methodology/principal findings</h4>We investigated the morphology of the brain in adolescents with IAD (N = 18) using an optimized voxel-based morphometry (VBM) technique, and studied the white matter fractional anisotropy (FA) changes using the diffusion tensor imaging (DTI) method, linking these brain structural measures to the duration of IAD. We provided evidences demonstrating the multiple structural changes of the brain in IAD subjects. VBM results indicated the decreased gray matter volume in the bilateral dorsolateral prefrontal cortex (DLPFC), the supplementary motor area (SMA), the orbitofrontal cortex (OFC), the cerebellum and the left rostral ACC (rACC). DTI analysis revealed the enhanced FA value of the left posterior limb of the internal capsule (PLIC) and reduced FA value in the white matter within the right parahippocampal gyrus (PHG). Gray matter volumes of the DLPFC, rACC, SMA, and white matter FA changes of the PLIC were significantly correlated with the duration of internet addiction in the adolescents with IAD.<h4>Conclusions</h4>Our results suggested that long-term internet addiction would result in brain structural alterations, which probably contributed to chronic dysfunction in subjects with IAD. The current study may shed further light on the potential brain effects of IAD.
format	article
author	Kai Yuan Wei Qin Guihong Wang Fang Zeng Liyan Zhao Xuejuan Yang Peng Liu Jixin Liu Jinbo Sun Karen M von Deneen Qiyong Gong Yijun Liu Jie Tian
author_facet	Kai Yuan Wei Qin Guihong Wang Fang Zeng Liyan Zhao Xuejuan Yang Peng Liu Jixin Liu Jinbo Sun Karen M von Deneen Qiyong Gong Yijun Liu Jie Tian
author_sort	Kai Yuan
title	Microstructure abnormalities in adolescents with internet addiction disorder.
title_short	Microstructure abnormalities in adolescents with internet addiction disorder.
title_full	Microstructure abnormalities in adolescents with internet addiction disorder.
title_fullStr	Microstructure abnormalities in adolescents with internet addiction disorder.
title_full_unstemmed	Microstructure abnormalities in adolescents with internet addiction disorder.
title_sort	microstructure abnormalities in adolescents with internet addiction disorder.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a911b7c9e0c34dbe8ed2ac89954ca60a
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_version_	1718424246924869632

Microstructure abnormalities in adolescents with internet addiction disorder.

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