Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
Single-molecule sequencing (SMS) such as Pacific Biosciences and Oxford Nanopore generate long reads with high error rate. Here, the authors develop Longshot, a computational method that detects and phases single nucleotide variants (SNV) in diploid genomes using SMS data.
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/a914015fa7154b73858b882af20bfb66 |
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| Sumario: | Single-molecule sequencing (SMS) such as Pacific Biosciences and Oxford Nanopore generate long reads with high error rate. Here, the authors develop Longshot, a computational method that detects and phases single nucleotide variants (SNV) in diploid genomes using SMS data. |
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