Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing

Single-molecule sequencing (SMS) such as Pacific Biosciences and Oxford Nanopore generate long reads with high error rate. Here, the authors develop Longshot, a computational method that detects and phases single nucleotide variants (SNV) in diploid genomes using SMS data.

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Detalles Bibliográficos
Autores principales:	Peter Edge, Vikas Bansal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a914015fa7154b73858b882af20bfb66
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spelling	oai:doaj.org-article:a914015fa7154b73858b882af20bfb662021-12-02T14:40:19ZLongshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing10.1038/s41467-019-12493-y2041-1723https://doaj.org/article/a914015fa7154b73858b882af20bfb662019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12493-yhttps://doaj.org/toc/2041-1723Single-molecule sequencing (SMS) such as Pacific Biosciences and Oxford Nanopore generate long reads with high error rate. Here, the authors develop Longshot, a computational method that detects and phases single nucleotide variants (SNV) in diploid genomes using SMS data.Peter EdgeVikas BansalNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter Edge Vikas Bansal Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
description	Single-molecule sequencing (SMS) such as Pacific Biosciences and Oxford Nanopore generate long reads with high error rate. Here, the authors develop Longshot, a computational method that detects and phases single nucleotide variants (SNV) in diploid genomes using SMS data.
format	article
author	Peter Edge Vikas Bansal
author_facet	Peter Edge Vikas Bansal
author_sort	Peter Edge
title	Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
title_short	Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
title_full	Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
title_fullStr	Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
title_full_unstemmed	Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
title_sort	longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a914015fa7154b73858b882af20bfb66
work_keys_str_mv	AT peteredge longshotenablesaccuratevariantcallingindiploidgenomesfromsinglemoleculelongreadsequencing AT vikasbansal longshotenablesaccuratevariantcallingindiploidgenomesfromsinglemoleculelongreadsequencing
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Longshot enables accurate variant calling in diploid genomes from single-molecule long read sequencing

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