Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.

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Autores principales:	Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Bürli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, Jose A. Apud, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D. G. McKay, Andrew E. Jaffe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf
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spelling	oai:doaj.org-article:a91415f76f3b4ff6b00a1fb9ef500aaf2021-12-02T17:31:40ZDissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs10.1038/s41467-019-14266-z2041-1723https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14266-zhttps://doaj.org/toc/2041-1723Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.Emily E. BurkeJoshua G. ChenowethJoo Heon ShinLeonardo Collado-TorresSuel-Kee KimNicola MicaliYanhong WangCarlo ColantuoniRichard E. StraubDaniel J. HoeppnerHuei-Ying ChenAlana SellersKamel ShibbaniGregory R. HamerskyMarcelo Diaz BustamanteBaDoi N. PhanWilliam S. UlrichCristian ValenciaAmritha JaishankarAmanda J. PriceAnandita RajpurohitStephen A. SemickRoland W. BürliJames C. BarrowDaniel J. HilerStephanie C. PageKeri MartinowichThomas M. HydeJoel E. KleinmanKaren F. BermanJose A. ApudAlan J. CrossNicholas J. BrandonDaniel R. WeinbergerBrady J. MaherRonald D. G. McKayAndrew E. JaffeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
description	Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocytes results in mutually synergistic maturation.
format	article
author	Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe
author_facet	Emily E. Burke Joshua G. Chenoweth Joo Heon Shin Leonardo Collado-Torres Suel-Kee Kim Nicola Micali Yanhong Wang Carlo Colantuoni Richard E. Straub Daniel J. Hoeppner Huei-Ying Chen Alana Sellers Kamel Shibbani Gregory R. Hamersky Marcelo Diaz Bustamante BaDoi N. Phan William S. Ulrich Cristian Valencia Amritha Jaishankar Amanda J. Price Anandita Rajpurohit Stephen A. Semick Roland W. Bürli James C. Barrow Daniel J. Hiler Stephanie C. Page Keri Martinowich Thomas M. Hyde Joel E. Kleinman Karen F. Berman Jose A. Apud Alan J. Cross Nicholas J. Brandon Daniel R. Weinberger Brady J. Maher Ronald D. G. McKay Andrew E. Jaffe
author_sort	Emily E. Burke
title	Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
title_short	Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
title_full	Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
title_fullStr	Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
title_full_unstemmed	Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
title_sort	dissecting transcriptomic signatures of neuronal differentiation and maturation using ipscs
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf
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Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs

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