Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance

The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted by targeting the EGFR-MEK-ERK pathway.

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Autores principales:	Fang Tai, Kunxiang Gong, Kai Song, Yanling He, Jian Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a914ed1c1cbf44228fd79d64b6148da8
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spelling	oai:doaj.org-article:a914ed1c1cbf44228fd79d64b6148da82021-12-02T15:39:17ZEnhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance10.1038/s41467-019-14083-42041-1723https://doaj.org/article/a914ed1c1cbf44228fd79d64b6148da82020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14083-4https://doaj.org/toc/2041-1723The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted by targeting the EGFR-MEK-ERK pathway.Fang TaiKunxiang GongKai SongYanling HeJian ShiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fang Tai Kunxiang Gong Kai Song Yanling He Jian Shi Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
description	The clinical use of BET inhibitors (BETi) is limited by primary and acquired resistance. Here, the authors report that BETi resistance is determined by JunD/RSK3 signalling activation induced by the loss of BRD4/Foxd3/miR-548d-3p, which can be reverted by targeting the EGFR-MEK-ERK pathway.
format	article
author	Fang Tai Kunxiang Gong Kai Song Yanling He Jian Shi
author_facet	Fang Tai Kunxiang Gong Kai Song Yanling He Jian Shi
author_sort	Fang Tai
title	Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
title_short	Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
title_full	Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
title_fullStr	Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
title_full_unstemmed	Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance
title_sort	enhanced jund/rsk3 signalling due to loss of brd4/foxd3/mir-548d-3p axis determines bet inhibition resistance
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/a914ed1c1cbf44228fd79d64b6148da8
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Enhanced JunD/RSK3 signalling due to loss of BRD4/FOXD3/miR-548d-3p axis determines BET inhibition resistance

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