Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults

Abstract This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45–65 years with BMI 25–29.9 kg/m2 received a daily dose of the Lab...

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Autores principales:	D. R. Michael, T. S. Davies, A. A. Jack, G. Masetti, J. R. Marchesi, D. Wang, B. H. Mullish, S. F. Plummer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a917c82bf75b4d98b17f51fb8bb2ba4b
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spelling	oai:doaj.org-article:a917c82bf75b4d98b17f51fb8bb2ba4b2021-12-02T15:13:01ZDaily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults10.1038/s41598-020-78285-32045-2322https://doaj.org/article/a917c82bf75b4d98b17f51fb8bb2ba4b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78285-3https://doaj.org/toc/2045-2322Abstract This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45–65 years with BMI 25–29.9 kg/m2 received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, p < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, p < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, p < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.D. R. MichaelT. S. DaviesA. A. JackG. MasettiJ. R. MarchesiD. WangB. H. MullishS. F. PlummerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q D. R. Michael T. S. Davies A. A. Jack G. Masetti J. R. Marchesi D. Wang B. H. Mullish S. F. Plummer Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
description	Abstract This 9-month randomised, parallel, double-blind, single-centre, placebo-controlled study (PROBE, ISRCTN18030882) assessed the impact of probiotic supplementation on bodyweight. Seventy overweight Bulgarian participants aged 45–65 years with BMI 25–29.9 kg/m2 received a daily dose of the Lab4P probiotic comprising lactobacilli and bifidobacteria (50 billion cfu/day). Participants maintained their normal diet and lifestyle over the duration of the study. The primary outcome was change from baseline in body weight and secondary outcomes included changes in waist circumference, hip circumference and blood pressure. A significant between group decrease in body weight (3.16 kg, 95% CI 3.94, 2.38, p < 0.0001) was detected favouring the probiotic group. Supplementation also resulted in significant between group decreases in waist circumference (2.58 cm, 95% CI 3.23, 1.94, p < 0.0001) and hip circumference (2.66 cm, 95% CI 3.28, 2.05, p < 0.0001) but no changes in blood pressure were observed. These findings support the outcomes of a previous shorter-term Lab4P intervention study in overweight and obese participants (PROMAGEN, ISRCTN12562026). We conclude that Lab4P has consistent weight modulation capability in free-living overweight adults.
format	article
author	D. R. Michael T. S. Davies A. A. Jack G. Masetti J. R. Marchesi D. Wang B. H. Mullish S. F. Plummer
author_facet	D. R. Michael T. S. Davies A. A. Jack G. Masetti J. R. Marchesi D. Wang B. H. Mullish S. F. Plummer
author_sort	D. R. Michael
title	Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
title_short	Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
title_full	Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
title_fullStr	Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
title_full_unstemmed	Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults
title_sort	daily supplementation with the lab4p probiotic consortium induces significant weight loss in overweight adults
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a917c82bf75b4d98b17f51fb8bb2ba4b
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Daily supplementation with the Lab4P probiotic consortium induces significant weight loss in overweight adults

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