Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via macrophage-mediated immunoregulatory responses.

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Autores principales:	Teruo Kusano, Driss Ehirchiou, Tomohiro Matsumura, Veronique Chobaz, Sonia Nasi, Mariela Castelblanco, Alexander So, Christine Lavanchy, Hans Acha-Orbea, Takeshi Nishino, Ken Okamoto, Nathalie Busso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a917fab180ef4bcfad65767813174f1d
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spelling	oai:doaj.org-article:a917fab180ef4bcfad65767813174f1d2021-12-02T14:39:19ZTargeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth10.1038/s41467-019-12565-z2041-1723https://doaj.org/article/a917fab180ef4bcfad65767813174f1d2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12565-zhttps://doaj.org/toc/2041-1723The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via macrophage-mediated immunoregulatory responses.Teruo KusanoDriss EhirchiouTomohiro MatsumuraVeronique ChobazSonia NasiMariela CastelblancoAlexander SoChristine LavanchyHans Acha-OrbeaTakeshi NishinoKen OkamotoNathalie BussoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Teruo Kusano Driss Ehirchiou Tomohiro Matsumura Veronique Chobaz Sonia Nasi Mariela Castelblanco Alexander So Christine Lavanchy Hans Acha-Orbea Takeshi Nishino Ken Okamoto Nathalie Busso Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
description	The roles of the convertible forms, xanthine dehydrogenase (XDH) and xanthine oxidase (XO) during tumorigenesis is not known. Here, the authors develop XDH-stable and XO-locked knock-in (ki) mice and show increased tumor growth in XO ki mice, via macrophage-mediated immunoregulatory responses.
format	article
author	Teruo Kusano Driss Ehirchiou Tomohiro Matsumura Veronique Chobaz Sonia Nasi Mariela Castelblanco Alexander So Christine Lavanchy Hans Acha-Orbea Takeshi Nishino Ken Okamoto Nathalie Busso
author_facet	Teruo Kusano Driss Ehirchiou Tomohiro Matsumura Veronique Chobaz Sonia Nasi Mariela Castelblanco Alexander So Christine Lavanchy Hans Acha-Orbea Takeshi Nishino Ken Okamoto Nathalie Busso
author_sort	Teruo Kusano
title	Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
title_short	Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
title_full	Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
title_fullStr	Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
title_full_unstemmed	Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
title_sort	targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a917fab180ef4bcfad65767813174f1d
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Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth

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