A piggyBac-based platform for genome editing and clonal rhesus macaque iPSC line derivation

Abstract Non-human primates (NHPs) are, due to their close phylogenetic relationship to humans, excellent animal models to study clinically relevant mutations. However, the toolbox for the genetic modification of NHPs is less developed than those for other species like mice. Therefore, it is necessa...

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Auteurs principaux: Ignacio Rodriguez-Polo, Sophie Mißbach, Stoyan Petkov, Felix Mattern, Anna Maierhofer, Iga Grządzielewska, Yuliia Tereshchenko, Daniel Urrutia-Cabrera, Thomas Haaf, Ralf Dressel, Iris Bartels, Rüdiger Behr
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/a91a5aa2c75a42bd99754c8131f457a6
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