Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy

Gene therapy has continuously evolved throughout the years since its first proposal to develop more specific and effective transfection, capable of treating a myriad of health conditions. Viral vectors are some of the most common and most efficient vehicles for gene transfer. However, the safe and e...

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Autores principales:	Juliana Sitta, Candace M. Howard
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gene therapy cancer metastasis systemic targeting viral vectors Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/a91c37940d924f2f9abbb8d7466a7518
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spelling	oai:doaj.org-article:a91c37940d924f2f9abbb8d7466a75182021-11-11T16:57:22ZApplications of Ultrasound-Mediated Drug Delivery and Gene Therapy10.3390/ijms2221114911422-00671661-6596https://doaj.org/article/a91c37940d924f2f9abbb8d7466a75182021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11491https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Gene therapy has continuously evolved throughout the years since its first proposal to develop more specific and effective transfection, capable of treating a myriad of health conditions. Viral vectors are some of the most common and most efficient vehicles for gene transfer. However, the safe and effective delivery of gene therapy remains a major obstacle. Ultrasound contrast agents in the form of microbubbles have provided a unique solution to fulfill the need to shield the vectors from the host immune system and the need for site specific targeted therapy. Since the discovery of the biophysical and biological effects of microbubble sonification, multiple developments have been made to enhance its applicability in targeted drug delivery. The concurrent development of viral vectors and recent research on dual vector strategies have shown promising results. This review will explore the mechanisms and recent advancements in the knowledge of ultrasound-mediated microbubbles in targeting gene and drug therapy.Juliana SittaCandace M. HowardMDPI AGarticlegene therapycancermetastasissystemic targetingviral vectorsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11491, p 11491 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gene therapy cancer metastasis systemic targeting viral vectors Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	gene therapy cancer metastasis systemic targeting viral vectors Biology (General) QH301-705.5 Chemistry QD1-999 Juliana Sitta Candace M. Howard Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
description	Gene therapy has continuously evolved throughout the years since its first proposal to develop more specific and effective transfection, capable of treating a myriad of health conditions. Viral vectors are some of the most common and most efficient vehicles for gene transfer. However, the safe and effective delivery of gene therapy remains a major obstacle. Ultrasound contrast agents in the form of microbubbles have provided a unique solution to fulfill the need to shield the vectors from the host immune system and the need for site specific targeted therapy. Since the discovery of the biophysical and biological effects of microbubble sonification, multiple developments have been made to enhance its applicability in targeted drug delivery. The concurrent development of viral vectors and recent research on dual vector strategies have shown promising results. This review will explore the mechanisms and recent advancements in the knowledge of ultrasound-mediated microbubbles in targeting gene and drug therapy.
format	article
author	Juliana Sitta Candace M. Howard
author_facet	Juliana Sitta Candace M. Howard
author_sort	Juliana Sitta
title	Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
title_short	Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
title_full	Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
title_fullStr	Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
title_full_unstemmed	Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy
title_sort	applications of ultrasound-mediated drug delivery and gene therapy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a91c37940d924f2f9abbb8d7466a7518
work_keys_str_mv	AT julianasitta applicationsofultrasoundmediateddrugdeliveryandgenetherapy AT candacemhoward applicationsofultrasoundmediateddrugdeliveryandgenetherapy
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Applications of Ultrasound-Mediated Drug Delivery and Gene Therapy

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