Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdra...

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Autores principales: Llewellyn Mills, Ilan Dar-Nimrod, Ben Colagiuri
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a920abbf2e4c407083f351daea186547
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spelling oai:doaj.org-article:a920abbf2e4c407083f351daea1865472021-12-02T16:08:08ZEffect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms10.1038/s41598-017-08678-42045-2322https://doaj.org/article/a920abbf2e4c407083f351daea1865472017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08678-4https://doaj.org/toc/2045-2322Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal. After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee. Half the participants were told their coffee was caffeinated and half were told truthfully that it was decaffeinated. Participants told the coffee was caffeinated reported a greater reduction in withdrawal symptoms than those told it was decaffeinated. Differing genetic test result information produced no difference in reported withdrawal symptoms. These results indicate that information about the dose of caffeine administered can influence withdrawal symptoms, but that genetic information does not have a universal ability to produce nocebo effects across all sensory and cognitive domains.Llewellyn MillsIlan Dar-NimrodBen ColagiuriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Llewellyn Mills
Ilan Dar-Nimrod
Ben Colagiuri
Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
description Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal. After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee. Half the participants were told their coffee was caffeinated and half were told truthfully that it was decaffeinated. Participants told the coffee was caffeinated reported a greater reduction in withdrawal symptoms than those told it was decaffeinated. Differing genetic test result information produced no difference in reported withdrawal symptoms. These results indicate that information about the dose of caffeine administered can influence withdrawal symptoms, but that genetic information does not have a universal ability to produce nocebo effects across all sensory and cognitive domains.
format article
author Llewellyn Mills
Ilan Dar-Nimrod
Ben Colagiuri
author_facet Llewellyn Mills
Ilan Dar-Nimrod
Ben Colagiuri
author_sort Llewellyn Mills
title Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_short Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_full Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_fullStr Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_full_unstemmed Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_sort effect of genetic information and information about caffeine content on caffeine withdrawal symptoms
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a920abbf2e4c407083f351daea186547
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