Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdra...

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Autores principales:	Llewellyn Mills, Ilan Dar-Nimrod, Ben Colagiuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a920abbf2e4c407083f351daea186547
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spelling	oai:doaj.org-article:a920abbf2e4c407083f351daea1865472021-12-02T16:08:08ZEffect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms10.1038/s41598-017-08678-42045-2322https://doaj.org/article/a920abbf2e4c407083f351daea1865472017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08678-4https://doaj.org/toc/2045-2322Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal. After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee. Half the participants were told their coffee was caffeinated and half were told truthfully that it was decaffeinated. Participants told the coffee was caffeinated reported a greater reduction in withdrawal symptoms than those told it was decaffeinated. Differing genetic test result information produced no difference in reported withdrawal symptoms. These results indicate that information about the dose of caffeine administered can influence withdrawal symptoms, but that genetic information does not have a universal ability to produce nocebo effects across all sensory and cognitive domains.Llewellyn MillsIlan Dar-NimrodBen ColagiuriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Llewellyn Mills Ilan Dar-Nimrod Ben Colagiuri Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
description	Abstract This study sought to test the effect of genetic information and information about the caffeine content of a beverage on caffeine withdrawal, specifically if: (1) being informed that one has tested positive for a gene related to caffeine withdrawal can produce an exaggerated caffeine withdrawal response during abstinence; (2) belief that one has consumed caffeine leads to a reduction in withdrawal symptoms when no caffeine is consumed. Regular coffee drinkers were given a bogus genetic test and were told either that they had tested positive or negative for a gene related to withdrawal. After 24-hour caffeine abstinence withdrawal symptoms were measured using a self-report caffeine withdrawal scale, and then again after a cup of decaffeinated coffee. Half the participants were told their coffee was caffeinated and half were told truthfully that it was decaffeinated. Participants told the coffee was caffeinated reported a greater reduction in withdrawal symptoms than those told it was decaffeinated. Differing genetic test result information produced no difference in reported withdrawal symptoms. These results indicate that information about the dose of caffeine administered can influence withdrawal symptoms, but that genetic information does not have a universal ability to produce nocebo effects across all sensory and cognitive domains.
format	article
author	Llewellyn Mills Ilan Dar-Nimrod Ben Colagiuri
author_facet	Llewellyn Mills Ilan Dar-Nimrod Ben Colagiuri
author_sort	Llewellyn Mills
title	Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_short	Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_full	Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_fullStr	Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_full_unstemmed	Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms
title_sort	effect of genetic information and information about caffeine content on caffeine withdrawal symptoms
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a920abbf2e4c407083f351daea186547
work_keys_str_mv	AT llewellynmills effectofgeneticinformationandinformationaboutcaffeinecontentoncaffeinewithdrawalsymptoms AT ilandarnimrod effectofgeneticinformationandinformationaboutcaffeinecontentoncaffeinewithdrawalsymptoms AT bencolagiuri effectofgeneticinformationandinformationaboutcaffeinecontentoncaffeinewithdrawalsymptoms
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Effect of Genetic Information and Information About Caffeine Content on Caffeine Withdrawal Symptoms

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