Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

The mechanics of the migration of T cells into tumours is an important aspect of tumour immunity. Here the authors engineer complex 3D environments to explore functions of microtubules and cell contractility as strategies to enhance T cell migration in tumour microenvironments.

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Autores principales:	Erdem D. Tabdanov, Nelson J. Rodríguez-Merced, Alexander X. Cartagena-Rivera, Vikram V. Puram, Mackenzie K. Callaway, Ethan A. Ensminger, Emily J. Pomeroy, Kenta Yamamoto, Walker S. Lahr, Beau R. Webber, Branden S. Moriarity, Alexander S. Zhovmer, Paolo P. Provenzano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9258c06966543cda042cc7df55119b0
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spelling	oai:doaj.org-article:a9258c06966543cda042cc7df55119b02021-12-02T16:50:30ZEngineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments10.1038/s41467-021-22985-52041-1723https://doaj.org/article/a9258c06966543cda042cc7df55119b02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22985-5https://doaj.org/toc/2041-1723The mechanics of the migration of T cells into tumours is an important aspect of tumour immunity. Here the authors engineer complex 3D environments to explore functions of microtubules and cell contractility as strategies to enhance T cell migration in tumour microenvironments.Erdem D. TabdanovNelson J. Rodríguez-MercedAlexander X. Cartagena-RiveraVikram V. PuramMackenzie K. CallawayEthan A. EnsmingerEmily J. PomeroyKenta YamamotoWalker S. LahrBeau R. WebberBranden S. MoriarityAlexander S. ZhovmerPaolo P. ProvenzanoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erdem D. Tabdanov Nelson J. Rodríguez-Merced Alexander X. Cartagena-Rivera Vikram V. Puram Mackenzie K. Callaway Ethan A. Ensminger Emily J. Pomeroy Kenta Yamamoto Walker S. Lahr Beau R. Webber Branden S. Moriarity Alexander S. Zhovmer Paolo P. Provenzano Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
description	The mechanics of the migration of T cells into tumours is an important aspect of tumour immunity. Here the authors engineer complex 3D environments to explore functions of microtubules and cell contractility as strategies to enhance T cell migration in tumour microenvironments.
format	article
author	Erdem D. Tabdanov Nelson J. Rodríguez-Merced Alexander X. Cartagena-Rivera Vikram V. Puram Mackenzie K. Callaway Ethan A. Ensminger Emily J. Pomeroy Kenta Yamamoto Walker S. Lahr Beau R. Webber Branden S. Moriarity Alexander S. Zhovmer Paolo P. Provenzano
author_facet	Erdem D. Tabdanov Nelson J. Rodríguez-Merced Alexander X. Cartagena-Rivera Vikram V. Puram Mackenzie K. Callaway Ethan A. Ensminger Emily J. Pomeroy Kenta Yamamoto Walker S. Lahr Beau R. Webber Branden S. Moriarity Alexander S. Zhovmer Paolo P. Provenzano
author_sort	Erdem D. Tabdanov
title	Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
title_short	Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
title_full	Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
title_fullStr	Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
title_full_unstemmed	Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments
title_sort	engineering t cells to enhance 3d migration through structurally and mechanically complex tumor microenvironments
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a9258c06966543cda042cc7df55119b0
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Engineering T cells to enhance 3D migration through structurally and mechanically complex tumor microenvironments

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