The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni

Schistosomiasis (e.g. Schistosoma mansoni) is a neglected tropical disease caused by parasitic worms. It can advance from an acute (juvenile form) to chronic stage (adult form). Single-dose praziquantel (PZQ) is the only therapeutic drug option for adult schistosomiasis (SM) treatment, while its ina...

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Auteurs principaux:	Cauê Benito Scarim, Chung Man Chin
Format:	article
Langue:	EN
Publié:	Elsevier 2021
Sujets:	Schistosomiasis Schistosoma mansoni New compounds Nitro-based compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
Accès en ligne:	https://doaj.org/article/a92baab5891c4df9a31ba550d54e7a0b
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spelling	oai:doaj.org-article:a92baab5891c4df9a31ba550d54e7a0b2021-12-03T04:01:33ZThe use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni2772-417410.1016/j.ejmcr.2021.100001https://doaj.org/article/a92baab5891c4df9a31ba550d54e7a0b2021-07-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2772417421000017https://doaj.org/toc/2772-4174Schistosomiasis (e.g. Schistosoma mansoni) is a neglected tropical disease caused by parasitic worms. It can advance from an acute (juvenile form) to chronic stage (adult form). Single-dose praziquantel (PZQ) is the only therapeutic drug option for adult schistosomiasis (SM) treatment, while its inability to efficiently inhibit earlier larval stages. Its use does not eliminate risks regarding the formation of resistant worms. Thus, new drug candidates to treat SM are urgently needed. Acting as molecule scaffolds, heterocyclic-based azo compounds have shown potential in the treatment of various diseases, including SM. This review article examines several medicinal chemistry-related studies involving these pharmacophore classes (pyrrolidine, imidazole, triazole, and thiazole) from 2011 to 2021, with a focus on SM. Our aim is to facilitate the drug design of novel molecules by optimizing anthelmintic conjugates.Cauê Benito ScarimChung Man ChinElsevierarticleSchistosomiasisSchistosoma mansoniNew compoundsNitro-based compoundsPharmacy and materia medicaRS1-441Other systems of medicineRZ201-999ENEuropean Journal of Medicinal Chemistry Reports, Vol 1, Iss , Pp 100001- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schistosomiasis Schistosoma mansoni New compounds Nitro-based compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999
spellingShingle	Schistosomiasis Schistosoma mansoni New compounds Nitro-based compounds Pharmacy and materia medica RS1-441 Other systems of medicine RZ201-999 Cauê Benito Scarim Chung Man Chin The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
description	Schistosomiasis (e.g. Schistosoma mansoni) is a neglected tropical disease caused by parasitic worms. It can advance from an acute (juvenile form) to chronic stage (adult form). Single-dose praziquantel (PZQ) is the only therapeutic drug option for adult schistosomiasis (SM) treatment, while its inability to efficiently inhibit earlier larval stages. Its use does not eliminate risks regarding the formation of resistant worms. Thus, new drug candidates to treat SM are urgently needed. Acting as molecule scaffolds, heterocyclic-based azo compounds have shown potential in the treatment of various diseases, including SM. This review article examines several medicinal chemistry-related studies involving these pharmacophore classes (pyrrolidine, imidazole, triazole, and thiazole) from 2011 to 2021, with a focus on SM. Our aim is to facilitate the drug design of novel molecules by optimizing anthelmintic conjugates.
format	article
author	Cauê Benito Scarim Chung Man Chin
author_facet	Cauê Benito Scarim Chung Man Chin
author_sort	Cauê Benito Scarim
title	The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
title_short	The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
title_full	The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
title_fullStr	The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
title_full_unstemmed	The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni
title_sort	use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by schistosoma mansoni
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a92baab5891c4df9a31ba550d54e7a0b
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The use of heterocyclic-based azo compounds bearing pyrrolidine, imidazole, triazole, and thiazole moieties for the treatment of neglected tropical disease caused by Schistosoma mansoni

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