Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.

<h4>Background</h4>The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown. The aim of the present study was to challenge the ability of SVV, PPV...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ole Broch, Matthias Gruenewald, Jochen Renner, Patrick Meybohm, Jan Schöttler, Katharina Heß, Markus Steinfath, Berthold Bein
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a92d457cf4aa47069afac76536c6f700
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a92d457cf4aa47069afac76536c6f700
record_format	dspace
spelling	oai:doaj.org-article:a92d457cf4aa47069afac76536c6f7002021-11-18T07:57:40ZDynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.1932-620310.1371/journal.pone.0056267https://doaj.org/article/a92d457cf4aa47069afac76536c6f7002013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23418546/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown. The aim of the present study was to challenge the ability of SVV, PPV and GEDV to predict fluid responsiveness in a porcine model with pleural effusions.<h4>Methods</h4>Pigs were studied at baseline and after fluid loading with 8 ml kg(-1) 6% hydroxyethyl starch. After withdrawal of 8 ml kg(-1) blood and induction of pleural effusion up to 50 ml kg(-1) on either side, measurements at baseline and after fluid loading were repeated. Cardiac output, stroke volume, central venous pressure (CVP) and pulmonary occlusion pressure (PAOP) were obtained by pulmonary thermodilution, whereas GEDV was determined by transpulmonary thermodilution. SVV and PPV were monitored continuously by pulse contour analysis.<h4>Results</h4>Pleural effusion was associated with significant changes in lung compliance, peak airway pressure and stroke volume in both responders and non-responders. At baseline, SVV, PPV and GEDV reliably predicted fluid responsiveness (area under the curve 0.85 (p<0.001), 0.88 (p<0.001), 0.77 (p = 0.007). After induction of pleural effusion the ability of SVV, PPV and GEDV to predict fluid responsiveness was well preserved and also PAOP was predictive. Threshold values for SVV and PPV increased in presence of pleural effusion.<h4>Conclusions</h4>In this porcine model, bilateral pleural effusion did not affect the ability of SVV, PPV and GEDV to predict fluid responsiveness.Ole BrochMatthias GruenewaldJochen RennerPatrick MeybohmJan SchöttlerKatharina HeßMarkus SteinfathBerthold BeinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56267 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ole Broch Matthias Gruenewald Jochen Renner Patrick Meybohm Jan Schöttler Katharina Heß Markus Steinfath Berthold Bein Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
description	<h4>Background</h4>The ability of stroke volume variation (SVV), pulse pressure variation (PPV) and global end-diastolic volume (GEDV) for prediction of fluid responsiveness in presence of pleural effusion is unknown. The aim of the present study was to challenge the ability of SVV, PPV and GEDV to predict fluid responsiveness in a porcine model with pleural effusions.<h4>Methods</h4>Pigs were studied at baseline and after fluid loading with 8 ml kg(-1) 6% hydroxyethyl starch. After withdrawal of 8 ml kg(-1) blood and induction of pleural effusion up to 50 ml kg(-1) on either side, measurements at baseline and after fluid loading were repeated. Cardiac output, stroke volume, central venous pressure (CVP) and pulmonary occlusion pressure (PAOP) were obtained by pulmonary thermodilution, whereas GEDV was determined by transpulmonary thermodilution. SVV and PPV were monitored continuously by pulse contour analysis.<h4>Results</h4>Pleural effusion was associated with significant changes in lung compliance, peak airway pressure and stroke volume in both responders and non-responders. At baseline, SVV, PPV and GEDV reliably predicted fluid responsiveness (area under the curve 0.85 (p<0.001), 0.88 (p<0.001), 0.77 (p = 0.007). After induction of pleural effusion the ability of SVV, PPV and GEDV to predict fluid responsiveness was well preserved and also PAOP was predictive. Threshold values for SVV and PPV increased in presence of pleural effusion.<h4>Conclusions</h4>In this porcine model, bilateral pleural effusion did not affect the ability of SVV, PPV and GEDV to predict fluid responsiveness.
format	article
author	Ole Broch Matthias Gruenewald Jochen Renner Patrick Meybohm Jan Schöttler Katharina Heß Markus Steinfath Berthold Bein
author_facet	Ole Broch Matthias Gruenewald Jochen Renner Patrick Meybohm Jan Schöttler Katharina Heß Markus Steinfath Berthold Bein
author_sort	Ole Broch
title	Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
title_short	Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
title_full	Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
title_fullStr	Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
title_full_unstemmed	Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
title_sort	dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a92d457cf4aa47069afac76536c6f700
work_keys_str_mv	AT olebroch dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT matthiasgruenewald dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT jochenrenner dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT patrickmeybohm dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT janschottler dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT katharinaheß dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT markussteinfath dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion AT bertholdbein dynamicandvolumetricvariablesreliablypredictfluidresponsivenessinaporcinemodelwithpleuraleffusion
_version_	1718422749244817408

Dynamic and volumetric variables reliably predict fluid responsiveness in a porcine model with pleural effusion.

Ejemplares similares