The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 control...

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Autores principales:	Mohi Ahmed, Ruth Moon, Ravindra Singh Prajapati, Elysia James, M. Albert Basson, Andrea Streit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a92fb875cfc14184bbec21667fb5460f
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spelling	oai:doaj.org-article:a92fb875cfc14184bbec21667fb5460f2021-11-07T12:19:34ZThe chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration10.1038/s42003-021-02788-62399-3642https://doaj.org/article/a92fb875cfc14184bbec21667fb5460f2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02788-6https://doaj.org/toc/2399-3642To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 controls the expression of stress pathway components, which could help to explain how CHD7 haploinsufficiency causes changes in the ear associated with CHARGE syndrome.Mohi AhmedRuth MoonRavindra Singh PrajapatiElysia JamesM. Albert BassonAndrea StreitNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
description	To improve our understanding of the mechanisms that protect hair cells in the ear from stress-induced death, Ahmed et al delete the chromodomain helicase DNA-binding protein 7 (CHD7) in auditory neurons and hair cells in mice. They observe sensorineural hearing loss and demonstrate that CHD7 controls the expression of stress pathway components, which could help to explain how CHD7 haploinsufficiency causes changes in the ear associated with CHARGE syndrome.
format	article
author	Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit
author_facet	Mohi Ahmed Ruth Moon Ravindra Singh Prajapati Elysia James M. Albert Basson Andrea Streit
author_sort	Mohi Ahmed
title	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
title_short	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
title_full	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
title_fullStr	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
title_full_unstemmed	The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
title_sort	chromatin remodelling factor chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a92fb875cfc14184bbec21667fb5460f
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The chromatin remodelling factor Chd7 protects auditory neurons and sensory hair cells from stress-induced degeneration

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