Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture

Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Taiki Nakajima, Akihiro Nakahata, Naoki Yamada, Keiko Yoshizawa, Tomoaki M. Kato, Mio Iwasaki, Chengzhu Zhao, Hiroshi Kuroki, Makoto Ikeya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a931afc1a44f40fc91158434225321bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a931afc1a44f40fc91158434225321bb
record_format	dspace
spelling	oai:doaj.org-article:a931afc1a44f40fc91158434225321bb2021-12-02T16:45:48ZGrafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture10.1038/s41467-021-25328-62041-1723https://doaj.org/article/a931afc1a44f40fc91158434225321bb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25328-6https://doaj.org/toc/2041-1723Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function recovery after Achilles tendon injury via engraftment and paracrine effects.Taiki NakajimaAkihiro NakahataNaoki YamadaKeiko YoshizawaTomoaki M. KatoMio IwasakiChengzhu ZhaoHiroshi KurokiMakoto IkeyaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taiki Nakajima Akihiro Nakahata Naoki Yamada Keiko Yoshizawa Tomoaki M. Kato Mio Iwasaki Chengzhu Zhao Hiroshi Kuroki Makoto Ikeya Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
description	Tendon self-renewal occurs rarely and reconstructive surgery comes with significant limitations. Here the authors present an induced pluripotent stem cell-based method to generate tenocytes, analyze their developmental trajectory using scRNA-seq, and demonstrate their contribution to motor function recovery after Achilles tendon injury via engraftment and paracrine effects.
format	article
author	Taiki Nakajima Akihiro Nakahata Naoki Yamada Keiko Yoshizawa Tomoaki M. Kato Mio Iwasaki Chengzhu Zhao Hiroshi Kuroki Makoto Ikeya
author_facet	Taiki Nakajima Akihiro Nakahata Naoki Yamada Keiko Yoshizawa Tomoaki M. Kato Mio Iwasaki Chengzhu Zhao Hiroshi Kuroki Makoto Ikeya
author_sort	Taiki Nakajima
title	Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
title_short	Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
title_full	Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
title_fullStr	Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
title_full_unstemmed	Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture
title_sort	grafting of ips cell-derived tenocytes promotes motor function recovery after achilles tendon rupture
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a931afc1a44f40fc91158434225321bb
work_keys_str_mv	AT taikinakajima graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT akihironakahata graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT naokiyamada graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT keikoyoshizawa graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT tomoakimkato graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT mioiwasaki graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT chengzhuzhao graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT hiroshikuroki graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture AT makotoikeya graftingofipscellderivedtenocytespromotesmotorfunctionrecoveryafterachillestendonrupture
_version_	1718383472409575424

Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture

Ejemplares similares