Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea

&Aring;ke Tegelberg,1,4,5 Bo Wilhelmsson,2 Nina Erixon-Lindroth,6 Leif H Lindstr&ouml;m3,41Department of Stomatognathic Physiology, 2Department of Otorhinolaryngology, 3Department of Psychiatry, Central Hospital, V&auml;ster&aring;s, Sweden; 4Centre for Clinical Resea...

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Autores principales:	Tegelberg &Aring;, Wilhelmsson B, Erixon-Lindroth N, Lindstr&ouml;m LH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/a9321171250349c2acfd13f5dbb4e7a0
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spelling	oai:doaj.org-article:a9321171250349c2acfd13f5dbb4e7a02021-12-02T01:11:02ZImproved cognitive functions after treatment with an oral appliance in obstructive sleep apnea1179-1608https://doaj.org/article/a9321171250349c2acfd13f5dbb4e7a02012-08-01T00:00:00Zhttp://www.dovepress.com/improved-cognitive-functions-after-treatment-with-an-oral-appliance-in-a10784https://doaj.org/toc/1179-1608&Aring;ke Tegelberg,1,4,5 Bo Wilhelmsson,2 Nina Erixon-Lindroth,6 Leif H Lindstr&ouml;m3,41Department of Stomatognathic Physiology, 2Department of Otorhinolaryngology, 3Department of Psychiatry, Central Hospital, V&auml;ster&aring;s, Sweden; 4Centre for Clinical Research, Uppsala University, Central Hospital, V&auml;ster&aring;s, Sweden; 5Faculty of Odontology, Malm&ouml; University, Malm&ouml;, Sweden; 6Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenObjective: The objective of this study was to evaluate the effect of oral appliance (OA) treatment on cognitive functions in patients with obstructive sleep apnea (OSA).Materials and methods: In a prospective study, 50 male patients with verified moderate-to-severe OSA received an OA with mandibular advancement. The cognitive functions assessed included working memory, vigilance, executive functioning, and mental pace, measured before as well as after 6 months of treatment. Somnography was used to measure physiological treatment effects. Forty-three patients completed the 6-month follow-up study.Results: All domains of cognitive functioning measured improved after 6 months of treatment with an OA (P &lt; 0.001). The apnea/hypopnea- and oxygen desaturation-indices decreased significantly after treatment (P &lt; 0.01). An obvious treatment response was reached in 60% of the patients, and 54% of the patients had recovered ie, had normalized breathing during sleep.Conclusion: OA with mandibular advancement is a treatment modality for the physiological symptoms of OSA, and may have a positive impact on cognitive functions, after only 6 months of treatment.Keywords: clinical trial, cognition, oral appliance, sleep apnea, treatmentTegelberg &Aring;Wilhelmsson BErixon-Lindroth NLindstr&ouml;m LHDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2012, Iss default, Pp 89-96 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Tegelberg &Aring; Wilhelmsson B Erixon-Lindroth N Lindstr&ouml;m LH Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
description	&Aring;ke Tegelberg,1,4,5 Bo Wilhelmsson,2 Nina Erixon-Lindroth,6 Leif H Lindstr&ouml;m3,41Department of Stomatognathic Physiology, 2Department of Otorhinolaryngology, 3Department of Psychiatry, Central Hospital, V&auml;ster&aring;s, Sweden; 4Centre for Clinical Research, Uppsala University, Central Hospital, V&auml;ster&aring;s, Sweden; 5Faculty of Odontology, Malm&ouml; University, Malm&ouml;, Sweden; 6Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenObjective: The objective of this study was to evaluate the effect of oral appliance (OA) treatment on cognitive functions in patients with obstructive sleep apnea (OSA).Materials and methods: In a prospective study, 50 male patients with verified moderate-to-severe OSA received an OA with mandibular advancement. The cognitive functions assessed included working memory, vigilance, executive functioning, and mental pace, measured before as well as after 6 months of treatment. Somnography was used to measure physiological treatment effects. Forty-three patients completed the 6-month follow-up study.Results: All domains of cognitive functioning measured improved after 6 months of treatment with an OA (P &lt; 0.001). The apnea/hypopnea- and oxygen desaturation-indices decreased significantly after treatment (P &lt; 0.01). An obvious treatment response was reached in 60% of the patients, and 54% of the patients had recovered ie, had normalized breathing during sleep.Conclusion: OA with mandibular advancement is a treatment modality for the physiological symptoms of OSA, and may have a positive impact on cognitive functions, after only 6 months of treatment.Keywords: clinical trial, cognition, oral appliance, sleep apnea, treatment
format	article
author	Tegelberg &Aring; Wilhelmsson B Erixon-Lindroth N Lindstr&ouml;m LH
author_facet	Tegelberg &Aring; Wilhelmsson B Erixon-Lindroth N Lindstr&ouml;m LH
author_sort	Tegelberg &Aring;
title	Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
title_short	Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
title_full	Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
title_fullStr	Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
title_full_unstemmed	Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
title_sort	improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/a9321171250349c2acfd13f5dbb4e7a0
work_keys_str_mv	AT tegelbergamparing improvedcognitivefunctionsaftertreatmentwithanoralapplianceinobstructivesleepapnea AT wilhelmssonb improvedcognitivefunctionsaftertreatmentwithanoralapplianceinobstructivesleepapnea AT erixonlindrothn improvedcognitivefunctionsaftertreatmentwithanoralapplianceinobstructivesleepapnea AT lindstrampoumlmlh improvedcognitivefunctionsaftertreatmentwithanoralapplianceinobstructivesleepapnea
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Improved cognitive functions after treatment with an oral appliance in obstructive sleep apnea

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