Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population

Aim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with T...

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Autores principales:	Irina Arkad'evna Bondar', Maksim Leonidovich Filipenko, Olesya Yur'evna Shabel'nikova, Ekaterina Alexandrovna Sokolova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2013
Materias:	type 2 diabetes mellitus genetics beta-cell dysfunction insulin resistance pparg2 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/a93672b587254939ad789a2ac072e8ed
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spelling	oai:doaj.org-article:a93672b587254939ad789a2ac072e8ed2021-11-14T09:00:18ZRs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population2072-03512072-037810.14341/DM2013417-22https://doaj.org/article/a93672b587254939ad789a2ac072e8ed2013-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/3846https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with TaqMan technique, implementing allele-specific real-time PCR. Results. Analysis shows that allelic frequency distribution of rs1801282 variant of PPARG2 gene and rs7903146 variant of TCF7L2 differs significantly between the study and control groups (OR [CI 95%]=1.44 [1.12?1.85], p=0.005 and OR [CI 95%]=1.57 [1.17?2.10], p=0.003, respectively). T2DM patients with T/T genotype of rs7903146 variant of TCF7L2 gene had lower BMI (p=0.02). Observed combination of risk alleles reached 99%. Combined beta-cell dysfunction and insulin resistance genotypes were identified in 56% of tested subjects, isolated insulin resistance ? in 42.2% of subjects, and isolated beta-cell dysfunction ? in 0.8% of subjects. Conclusion. Our data shows that carrier state of 12Pro rs1801284 variant of PPARG2 gene and T-allele rs7903146 variant of TCF7L2 gene are associated with T2DM in Novosibirsk population, increasing its risk 1.44 and 1.57 times, respectively. Combination of these polymorphisms was observed in 99% of patients with T2DM.Irina Arkad'evna Bondar'Maksim Leonidovich FilipenkoOlesya Yur'evna Shabel'nikovaEkaterina Alexandrovna SokolovaEndocrinology Research Centrearticletype 2 diabetes mellitusgeneticsbeta-cell dysfunctioninsulin resistancepparg2tcf7l2Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 16, Iss 4, Pp 17-22 (2013)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus genetics beta-cell dysfunction insulin resistance pparg2 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus genetics beta-cell dysfunction insulin resistance pparg2 tcf7l2 Nutritional diseases. Deficiency diseases RC620-627 Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
description	Aim. To investigate the association of polymorphisms in TCF7L2 and PPARG2 genes with type 2 diabetes mellitus (T2DM) in Novosibirsk population. Materials and Methods. We examined 391 patients with T2DM and 556 individuals with normal glucose metabolism. Allelic identification was performed with TaqMan technique, implementing allele-specific real-time PCR. Results. Analysis shows that allelic frequency distribution of rs1801282 variant of PPARG2 gene and rs7903146 variant of TCF7L2 differs significantly between the study and control groups (OR [CI 95%]=1.44 [1.12?1.85], p=0.005 and OR [CI 95%]=1.57 [1.17?2.10], p=0.003, respectively). T2DM patients with T/T genotype of rs7903146 variant of TCF7L2 gene had lower BMI (p=0.02). Observed combination of risk alleles reached 99%. Combined beta-cell dysfunction and insulin resistance genotypes were identified in 56% of tested subjects, isolated insulin resistance ? in 42.2% of subjects, and isolated beta-cell dysfunction ? in 0.8% of subjects. Conclusion. Our data shows that carrier state of 12Pro rs1801284 variant of PPARG2 gene and T-allele rs7903146 variant of TCF7L2 gene are associated with T2DM in Novosibirsk population, increasing its risk 1.44 and 1.57 times, respectively. Combination of these polymorphisms was observed in 99% of patients with T2DM.
format	article
author	Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova
author_facet	Irina Arkad'evna Bondar' Maksim Leonidovich Filipenko Olesya Yur'evna Shabel'nikova Ekaterina Alexandrovna Sokolova
author_sort	Irina Arkad'evna Bondar'
title	Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
title_short	Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
title_full	Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
title_fullStr	Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
title_full_unstemmed	Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population
title_sort	rs7903146 variant of tcf7l2 gene and rs18012824 variant of pparg2 gene (pro12ala) are associated with type 2 diabetes mellitus in novosibirsk population
publisher	Endocrinology Research Centre
publishDate	2013
url	https://doaj.org/article/a93672b587254939ad789a2ac072e8ed
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Rs7903146 variant of TCF7L2 gene and rs18012824 variant of PPARG2 gene (Pro12Ala) are associated with type 2 diabetes mellitus in Novosibirsk population

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