Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid

A novel voltammetric sensor based on CeO2·Fe2O3 nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provid...

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Autores principales:	Guzel Ziyatdinova, Liliya Gimadutdinova
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metal oxide nanoparticles amperometric sensors electrooxidation lipoic acid pharmaceutical analysis Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/a93ec67cf319483796f4a306bce4bfff
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spelling	oai:doaj.org-article:a93ec67cf319483796f4a306bce4bfff2021-11-25T18:58:06ZCerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid10.3390/s212276391424-8220https://doaj.org/article/a93ec67cf319483796f4a306bce4bfff2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8220/21/22/7639https://doaj.org/toc/1424-8220A novel voltammetric sensor based on CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provides a 5.6-fold increase of the lipoic acid oxidation currents and a 20 mV anodic shift of the oxidation potential. The best voltammetric parameters have been obtained for the 0.5 mg mL<sup>−1</sup> dispersion of CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> NPs. Scanning electron microscopy (SEM) confirms the presence of spherical NPs of 25–60 nm, and their aggregates evenly distributed on the electrode surface and formed porous coverage. This leads to the 4.4-fold increase of the effective surface area vs. bare glassy carbon electrode (GCE). The sensor shows a significantly higher electron transfer rate. Electrooxidation of lipoic acid on CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> NPs modified GCE is an irreversible diffusion-controlled pH-independent process occurring with the participation of two electrons. The sensor gives a linear response to lipoic acid in the ranges of 0.075–7.5 and 7.5–100 μM with the detection limit of 0.053 μM. The sensor is selective towards lipoic acid in the presence of inorganic ions, ascorbic acid, saccharides, and other S-containing compounds. The sensor developed has been tested on the pharmaceutical dosage forms of lipoic acid.Guzel ZiyatdinovaLiliya GimadutdinovaMDPI AGarticlemetal oxide nanoparticlesamperometric sensorselectrooxidationlipoic acidpharmaceutical analysisChemical technologyTP1-1185ENSensors, Vol 21, Iss 7639, p 7639 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metal oxide nanoparticles amperometric sensors electrooxidation lipoic acid pharmaceutical analysis Chemical technology TP1-1185
spellingShingle	metal oxide nanoparticles amperometric sensors electrooxidation lipoic acid pharmaceutical analysis Chemical technology TP1-1185 Guzel Ziyatdinova Liliya Gimadutdinova Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
description	A novel voltammetric sensor based on CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> nanoparticles (NPs) has been developed for the determination of lipoic acid, playing an essential role in aerobic metabolism in the living organism. Sensor surface modification provides a 5.6-fold increase of the lipoic acid oxidation currents and a 20 mV anodic shift of the oxidation potential. The best voltammetric parameters have been obtained for the 0.5 mg mL<sup>−1</sup> dispersion of CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> NPs. Scanning electron microscopy (SEM) confirms the presence of spherical NPs of 25–60 nm, and their aggregates evenly distributed on the electrode surface and formed porous coverage. This leads to the 4.4-fold increase of the effective surface area vs. bare glassy carbon electrode (GCE). The sensor shows a significantly higher electron transfer rate. Electrooxidation of lipoic acid on CeO<sub>2</sub>·Fe<sub>2</sub>O<sub>3</sub> NPs modified GCE is an irreversible diffusion-controlled pH-independent process occurring with the participation of two electrons. The sensor gives a linear response to lipoic acid in the ranges of 0.075–7.5 and 7.5–100 μM with the detection limit of 0.053 μM. The sensor is selective towards lipoic acid in the presence of inorganic ions, ascorbic acid, saccharides, and other S-containing compounds. The sensor developed has been tested on the pharmaceutical dosage forms of lipoic acid.
format	article
author	Guzel Ziyatdinova Liliya Gimadutdinova
author_facet	Guzel Ziyatdinova Liliya Gimadutdinova
author_sort	Guzel Ziyatdinova
title	Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
title_short	Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
title_full	Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
title_fullStr	Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
title_full_unstemmed	Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid
title_sort	cerium(iv) and iron(iii) oxides nanoparticles based voltammetric sensor for the sensitive and selective determination of lipoic acid
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a93ec67cf319483796f4a306bce4bfff
work_keys_str_mv	AT guzelziyatdinova ceriumivandironiiioxidesnanoparticlesbasedvoltammetricsensorforthesensitiveandselectivedeterminationoflipoicacid AT liliyagimadutdinova ceriumivandironiiioxidesnanoparticlesbasedvoltammetricsensorforthesensitiveandselectivedeterminationoflipoicacid
_version_	1718410480926588928

Cerium(IV) and Iron(III) Oxides Nanoparticles Based Voltammetric Sensor for the Sensitive and Selective Determination of Lipoic Acid

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