The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke
Xiaoyi Yi,1 Xiangyang Zhu,1 Yong Zhou,1 Dongmei Zhang,2 Mengmeng Li,2 Yuting Zhu,1 Xiaoming Guo1 1Deparment of Neurology, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, Peopl...
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Dove Medical Press
2021
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oai:doaj.org-article:a93f20cf5a664d819ecd706d16e468432021-12-02T13:32:10ZThe Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke1178-2021https://doaj.org/article/a93f20cf5a664d819ecd706d16e468432021-03-01T00:00:00Zhttps://www.dovepress.com/the-combination-of-insulin-resistance-and-serum-interleukin-1beta-corr-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Xiaoyi Yi,1 Xiangyang Zhu,1 Yong Zhou,1 Dongmei Zhang,2 Mengmeng Li,2 Yuting Zhu,1 Xiaoming Guo1 1Deparment of Neurology, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of ChinaCorrespondence: Xiangyang ZhuDepartment of Neurology, Affiliated Hospital 2 of Nantong University, 6 Haier-Xiang North Road, Nantong, 226000, Jiangsu, People’s Republic of ChinaFax +86 513-85061148Email zhuxxyy2092@163.comPurpose: Previous studies have shown that insulin resistance and inflammation may be associated with the pathophysiological mechanisms of mood disorders. Here, we investigated whether homeostatic model assessment of insulin resistance (HOMA-IR) and serum interleukin-1β (IL-1β) in acute ischemic stroke patients might be associated with post-stroke depression (PSD).Materials and Methods: The prospective study was conducted in China from February 2019 to September 2020. HOMA-IR and clinical data were collected at the time of admission. Serum levels of IL-1β were determined with enzyme-linked immunosorbent assays. Symptoms of depression and anxiety were screened by using the Hamilton Depression and Anxiety Scale at 6 months after stroke, and PSD was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria. The association of potential risk factors with PSD was analyzed with multivariate logistic regression analysis. Finally, the ability of HOMA-IR and IL-1β to predict PSD was assessed with receiver operating characteristic curve.Results: A total of 305 people was included in the study; 65% were male, and the median age was 69.5± 11.8 years. At the 6-month follow-up, 113 patients (37.5%) showed depressive symptoms. In multivariate logistic regression analysis, HOMA-IR and IL-1β as graded variables were associated with an increased risk of PSD (P < 0.05). Receiver operating characteristic curve analysis indicated the highest sensitivity and specificity when the HOMA-IR and IL-1β were 1.96 and 38.71 pg/mL, respectively (P < 0.001). IL-1β improved the ability of HOMA-IR to diagnose PSD combined model area under the curve (AUC): 0.78; 95% CI: 0.72– 0.83; P < 0.001).Conclusion: This study suggests that HOMA-IR and IL-1β are strongly associated with PSD at 6 months after stroke in patients with acute ischemic stroke. These two factors together improve the ability for early PSD assessment.Keywords: insulin resistance, interleukin-1β, acute ischemic stroke, post-stroke depression, inflammationYi XZhu XZhou YZhang DLi MZhu YGuo XDove Medical Pressarticleinsulin resistanceinterleukin-1βacute ischemic strokepost-stroke depressioninflammationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 735-746 (2021) |
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DOAJ |
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EN |
| topic |
insulin resistance interleukin-1β acute ischemic stroke post-stroke depression inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
insulin resistance interleukin-1β acute ischemic stroke post-stroke depression inflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yi X Zhu X Zhou Y Zhang D Li M Zhu Y Guo X The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| description |
Xiaoyi Yi,1 Xiangyang Zhu,1 Yong Zhou,1 Dongmei Zhang,2 Mengmeng Li,2 Yuting Zhu,1 Xiaoming Guo1 1Deparment of Neurology, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of China; 2Clinical Research Center, Affiliated Hospital 2 of Nantong University, Nantong, People’s Republic of ChinaCorrespondence: Xiangyang ZhuDepartment of Neurology, Affiliated Hospital 2 of Nantong University, 6 Haier-Xiang North Road, Nantong, 226000, Jiangsu, People’s Republic of ChinaFax +86 513-85061148Email zhuxxyy2092@163.comPurpose: Previous studies have shown that insulin resistance and inflammation may be associated with the pathophysiological mechanisms of mood disorders. Here, we investigated whether homeostatic model assessment of insulin resistance (HOMA-IR) and serum interleukin-1β (IL-1β) in acute ischemic stroke patients might be associated with post-stroke depression (PSD).Materials and Methods: The prospective study was conducted in China from February 2019 to September 2020. HOMA-IR and clinical data were collected at the time of admission. Serum levels of IL-1β were determined with enzyme-linked immunosorbent assays. Symptoms of depression and anxiety were screened by using the Hamilton Depression and Anxiety Scale at 6 months after stroke, and PSD was diagnosed on the basis of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V) criteria. The association of potential risk factors with PSD was analyzed with multivariate logistic regression analysis. Finally, the ability of HOMA-IR and IL-1β to predict PSD was assessed with receiver operating characteristic curve.Results: A total of 305 people was included in the study; 65% were male, and the median age was 69.5± 11.8 years. At the 6-month follow-up, 113 patients (37.5%) showed depressive symptoms. In multivariate logistic regression analysis, HOMA-IR and IL-1β as graded variables were associated with an increased risk of PSD (P < 0.05). Receiver operating characteristic curve analysis indicated the highest sensitivity and specificity when the HOMA-IR and IL-1β were 1.96 and 38.71 pg/mL, respectively (P < 0.001). IL-1β improved the ability of HOMA-IR to diagnose PSD combined model area under the curve (AUC): 0.78; 95% CI: 0.72– 0.83; P < 0.001).Conclusion: This study suggests that HOMA-IR and IL-1β are strongly associated with PSD at 6 months after stroke in patients with acute ischemic stroke. These two factors together improve the ability for early PSD assessment.Keywords: insulin resistance, interleukin-1β, acute ischemic stroke, post-stroke depression, inflammation |
| format |
article |
| author |
Yi X Zhu X Zhou Y Zhang D Li M Zhu Y Guo X |
| author_facet |
Yi X Zhu X Zhou Y Zhang D Li M Zhu Y Guo X |
| author_sort |
Yi X |
| title |
The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| title_short |
The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| title_full |
The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| title_fullStr |
The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| title_full_unstemmed |
The Combination of Insulin Resistance and Serum Interleukin-1β Correlates with Post-Stroke Depression in Patients with Acute Ischemic Stroke |
| title_sort |
combination of insulin resistance and serum interleukin-1β correlates with post-stroke depression in patients with acute ischemic stroke |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/a93f20cf5a664d819ecd706d16e46843 |
| work_keys_str_mv |
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