Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study

Lucia Margari,1 Andrea De Giacomo,1 Francesco Craig,2 Roberto Palumbi,1 Antonia Peschechera,1 Mariella Margari,1 Francesca Picardi,3 Marina Caldarola,3 Marilena Anna Maghenzani,4 Franca Dicuonzo3 1Department of Basic Medical Sciences, Neuroscience and Sense Organs, Child Neuropsychiatry Unit, Unive...

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Autores principales:	Margari L, De Giacomo A, Craig F, Palumbi R, Peschechera A, Margari M, Picardi F, Caldarola M, Maghenzani MA, Dicuonzo F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	autism magnetic resonance neurodevelopmental disorder cognitive impairment neuroimaging brain metabolites. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a940c1237bf34bb7b70a7b28bbffe633
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spelling	oai:doaj.org-article:a940c1237bf34bb7b70a7b28bbffe6332021-12-02T07:31:26ZFrontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study1178-2021https://doaj.org/article/a940c1237bf34bb7b70a7b28bbffe6332018-07-01T00:00:00Zhttps://www.dovepress.com/frontal-lobe-metabolic-alterations-in-autism-spectrum-disorder-a-1h-ma-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Lucia Margari,1 Andrea De Giacomo,1 Francesco Craig,2 Roberto Palumbi,1 Antonia Peschechera,1 Mariella Margari,1 Francesca Picardi,3 Marina Caldarola,3 Marilena Anna Maghenzani,4 Franca Dicuonzo3 1Department of Basic Medical Sciences, Neuroscience and Sense Organs, Child Neuropsychiatry Unit, University of Bari Aldo Moro, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy; 2Scientific Institute, IRCCS E. Medea, Unit for Severe Disabilities in Developmental Age and Young Adults, Developmental Neurology and Neurorehabilitation, Brindisi, Italy; 3Department of Basic Medical Sciences, Neuroscience and Sense Organs, Neuroradiology Unit, University of Bari Aldo Moro, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy; 4Emergency Department, Anesthesia and Intensive Care Unit, University of Bari Aldo Moro, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy Purpose: Recently, neuroimaging studies were performed using 1H-magnetic resonance spectroscopy (1H-MRS), revealing a quantitative alteration of neurochemicals (such as neurotransmitters and metabolites) in several brain regions of patients with autism spectrum disorder (ASD). The involvement of the frontal lobe in the neurobiology of ASD has long been documented in the literature. Therefore, the aim of this study was to analyze the alterations of N-acetylaspartate/creatine (NAA/Cr) and choline/Cr (Cho/Cr) ratios in the frontal lobe subcortical white matter (WM) in ASD patients, in order to reveal any alteration of metabolites that might be the expression of specific clinical features of the disorder.Patients and methods: An 1H-MRS study of the frontal lobe subcortical WM was performed in 75 children with ASD and in 50 age-matched controls to evaluate the functional activity of this brain region.Results: NAA/Cr and Cho/Cr ratios were significantly altered in ASD, compared to control subjects. Moreover, in the ASD group, NAA/Cr was significantly lower in patients with a cognitive impairment.Conclusion: Results from this study confirm the existence of brain metabolites’ alterations in frontal lobe WM in children with ASD, supporting the relevance of this brain region in the clinical expressions of this disorder, including its role in the cognitive impairment. Further 1H-MRS investigations will allow to comprehensively explain the relationship between metabolic alteration in a specific brain region and specific clinical features of ASD. Keywords: autism, neurodevelopmental disorder, cognitive impairment, neuroimaging, brain metabolitesMargari LDe Giacomo ACraig FPalumbi RPeschechera AMargari MPicardi FCaldarola MMaghenzani MADicuonzo FDove Medical Pressarticleautismmagnetic resonanceneurodevelopmental disordercognitive impairmentneuroimagingbrain metabolites.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1871-1876 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism magnetic resonance neurodevelopmental disorder cognitive impairment neuroimaging brain metabolites. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	autism magnetic resonance neurodevelopmental disorder cognitive impairment neuroimaging brain metabolites. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Margari L De Giacomo A Craig F Palumbi R Peschechera A Margari M Picardi F Caldarola M Maghenzani MA Dicuonzo F Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
description	Lucia Margari,1 Andrea De Giacomo,1 Francesco Craig,2 Roberto Palumbi,1 Antonia Peschechera,1 Mariella Margari,1 Francesca Picardi,3 Marina Caldarola,3 Marilena Anna Maghenzani,4 Franca Dicuonzo3 1Department of Basic Medical Sciences, Neuroscience and Sense Organs, Child Neuropsychiatry Unit, University of Bari Aldo Moro, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy; 2Scientific Institute, IRCCS E. Medea, Unit for Severe Disabilities in Developmental Age and Young Adults, Developmental Neurology and Neurorehabilitation, Brindisi, Italy; 3Department of Basic Medical Sciences, Neuroscience and Sense Organs, Neuroradiology Unit, University of Bari Aldo Moro, Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Bari, Italy; 4Emergency Department, Anesthesia and Intensive Care Unit, University of Bari Aldo Moro, Azienda Ospedaliero-Universitaria Policlinico di Bari, Bari, Italy Purpose: Recently, neuroimaging studies were performed using 1H-magnetic resonance spectroscopy (1H-MRS), revealing a quantitative alteration of neurochemicals (such as neurotransmitters and metabolites) in several brain regions of patients with autism spectrum disorder (ASD). The involvement of the frontal lobe in the neurobiology of ASD has long been documented in the literature. Therefore, the aim of this study was to analyze the alterations of N-acetylaspartate/creatine (NAA/Cr) and choline/Cr (Cho/Cr) ratios in the frontal lobe subcortical white matter (WM) in ASD patients, in order to reveal any alteration of metabolites that might be the expression of specific clinical features of the disorder.Patients and methods: An 1H-MRS study of the frontal lobe subcortical WM was performed in 75 children with ASD and in 50 age-matched controls to evaluate the functional activity of this brain region.Results: NAA/Cr and Cho/Cr ratios were significantly altered in ASD, compared to control subjects. Moreover, in the ASD group, NAA/Cr was significantly lower in patients with a cognitive impairment.Conclusion: Results from this study confirm the existence of brain metabolites’ alterations in frontal lobe WM in children with ASD, supporting the relevance of this brain region in the clinical expressions of this disorder, including its role in the cognitive impairment. Further 1H-MRS investigations will allow to comprehensively explain the relationship between metabolic alteration in a specific brain region and specific clinical features of ASD. Keywords: autism, neurodevelopmental disorder, cognitive impairment, neuroimaging, brain metabolites
format	article
author	Margari L De Giacomo A Craig F Palumbi R Peschechera A Margari M Picardi F Caldarola M Maghenzani MA Dicuonzo F
author_facet	Margari L De Giacomo A Craig F Palumbi R Peschechera A Margari M Picardi F Caldarola M Maghenzani MA Dicuonzo F
author_sort	Margari L
title	Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
title_short	Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
title_full	Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
title_fullStr	Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
title_full_unstemmed	Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study
title_sort	frontal lobe metabolic alterations in autism spectrum disorder: a 1h-magnetic resonance spectroscopy study
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/a940c1237bf34bb7b70a7b28bbffe633
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Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study

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