Prospects and limitations of physiologically-based pharmacokinetic modelling for cross-species extrapolation

The transition from experimental findings in animal models to clinical applications in human patients is a key challenge in pharmacology and toxicology. To date, this step still inhibits a significant level of uncertainty explaining amongst others the continuously high attrition rates in pharmace...

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Bibliographic Details
Main Author: Lars Kuepfer
Format: article
Language:EN
Published: South Valley University 2019
Subjects:
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Online Access:https://doaj.org/article/a94188f39ce3415882c79a550fba59d8
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