TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers

Several C2 domain-containing proteins play key roles in tumorigenesis, signal transduction, and mediating protein–protein interactions. Tandem C2 domains nuclear protein (TC2N) is a tandem C2 domain-containing protein that is differentially expressed in several types of cancers and is closely associ...

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Autores principales:	Hanyang Li, He Fang, Li Chang, Shuang Qiu, Xiaojun Ren, Lidong Cao, Jinda Bian, Zhenxiao Wang, Yi Guo, Jiayin Lv, Zhihui Sun, Tiejun Wang, Bingjin Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	TC2N tumor-associated antigens (TAAs) cancer signal pathway molecular mechanism functional characterization Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/a944dbfad2144ca6be63a06a015a27e5
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spelling	oai:doaj.org-article:a944dbfad2144ca6be63a06a015a27e52021-12-02T06:03:59ZTC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers1664-322410.3389/fimmu.2021.764749https://doaj.org/article/a944dbfad2144ca6be63a06a015a27e52021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.764749/fullhttps://doaj.org/toc/1664-3224Several C2 domain-containing proteins play key roles in tumorigenesis, signal transduction, and mediating protein–protein interactions. Tandem C2 domains nuclear protein (TC2N) is a tandem C2 domain-containing protein that is differentially expressed in several types of cancers and is closely associated with tumorigenesis and tumor progression. Notably, TC2N has been identified as an oncogene in lung and gastric cancer but as a tumor suppressor gene in breast cancer. Recently, a large number of tumor-associated antigens (TAAs), such as heat shock proteins, alpha-fetoprotein, and carcinoembryonic antigen, have been identified in a variety of malignant tumors. Differences in the expression levels of TAAs between cancer cells and normal cells have led to these antigens being investigated as diagnostic and prognostic biomarkers and as novel targets in cancer treatment. In this review, we summarize the clinical characteristics of TC2N-positive cancers and potential mechanisms of action of TC2N in the occurrence and development of specific cancers. This article provides an exploration of TC2N as a potential target for the diagnosis and treatment of different types of cancers.Hanyang LiHanyang LiHe FangLi ChangShuang QiuXiaojun RenLidong CaoJinda BianZhenxiao WangYi GuoJiayin LvZhihui SunTiejun WangBingjin LiFrontiers Media S.A.articleTC2Ntumor-associated antigens (TAAs)cancersignal pathwaymolecular mechanismfunctional characterizationImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	TC2N tumor-associated antigens (TAAs) cancer signal pathway molecular mechanism functional characterization Immunologic diseases. Allergy RC581-607
spellingShingle	TC2N tumor-associated antigens (TAAs) cancer signal pathway molecular mechanism functional characterization Immunologic diseases. Allergy RC581-607 Hanyang Li Hanyang Li He Fang Li Chang Shuang Qiu Xiaojun Ren Lidong Cao Jinda Bian Zhenxiao Wang Yi Guo Jiayin Lv Zhihui Sun Tiejun Wang Bingjin Li TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
description	Several C2 domain-containing proteins play key roles in tumorigenesis, signal transduction, and mediating protein–protein interactions. Tandem C2 domains nuclear protein (TC2N) is a tandem C2 domain-containing protein that is differentially expressed in several types of cancers and is closely associated with tumorigenesis and tumor progression. Notably, TC2N has been identified as an oncogene in lung and gastric cancer but as a tumor suppressor gene in breast cancer. Recently, a large number of tumor-associated antigens (TAAs), such as heat shock proteins, alpha-fetoprotein, and carcinoembryonic antigen, have been identified in a variety of malignant tumors. Differences in the expression levels of TAAs between cancer cells and normal cells have led to these antigens being investigated as diagnostic and prognostic biomarkers and as novel targets in cancer treatment. In this review, we summarize the clinical characteristics of TC2N-positive cancers and potential mechanisms of action of TC2N in the occurrence and development of specific cancers. This article provides an exploration of TC2N as a potential target for the diagnosis and treatment of different types of cancers.
format	article
author	Hanyang Li Hanyang Li He Fang Li Chang Shuang Qiu Xiaojun Ren Lidong Cao Jinda Bian Zhenxiao Wang Yi Guo Jiayin Lv Zhihui Sun Tiejun Wang Bingjin Li
author_facet	Hanyang Li Hanyang Li He Fang Li Chang Shuang Qiu Xiaojun Ren Lidong Cao Jinda Bian Zhenxiao Wang Yi Guo Jiayin Lv Zhihui Sun Tiejun Wang Bingjin Li
author_sort	Hanyang Li
title	TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
title_short	TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
title_full	TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
title_fullStr	TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
title_full_unstemmed	TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers
title_sort	tc2n: a novel vital oncogene or tumor suppressor gene in cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a944dbfad2144ca6be63a06a015a27e5
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TC2N: A Novel Vital Oncogene or Tumor Suppressor Gene In Cancers

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