C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.

Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxidative and endoplasmic reticulum (ER) stress. Also...

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Autores principales:	Bedoor Qabazard, Samanza Ahmed, Ling Li, Volker M Arlt, Philip K Moore, Stephen R Stürzenbaum
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9489aeae4c74d0eaa9292ce1d843418
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spelling	oai:doaj.org-article:a9489aeae4c74d0eaa9292ce1d8434182021-11-18T08:47:42ZC. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.1932-620310.1371/journal.pone.0080135https://doaj.org/article/a9489aeae4c74d0eaa9292ce1d8434182013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260346/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxidative and endoplasmic reticulum (ER) stress. Also, cysl-2, a sulfhydrylase/cysteine synthase in C. elegans, was transcriptionally upregulated by GYY4137 treatment and the deletion of cysl-2 resulted in a significant reduction in lifespan which was partially recovered by the supplementation of GYY4137. Likewise, a mammalian cell culture system, GYY4137 was able to protect bovine aortic endothelial cells (BAECs) from oxidative stress and (H2O2)-induced cell death. Taken together, this provides further support that H2S exerts a protective function which is consistent with the longevity dividend theory. Overall, this study underlines the therapeutic potential of a slow-releasing H2S donor as regulators of the aging and cellular stress pathways.Bedoor QabazardSamanza AhmedLing LiVolker M ArltPhilip K MooreStephen R StürzenbaumPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80135 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bedoor Qabazard Samanza Ahmed Ling Li Volker M Arlt Philip K Moore Stephen R Stürzenbaum C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
description	Exogenous hydrogen sulfide (H2S) administration and endogenous H2S metabolism were explored in the nematode C. elegans. Chronic treatment with a slow-releasing H2S donor, GYY4137, extended median survival by 17-23% and increased tolerance towards oxidative and endoplasmic reticulum (ER) stress. Also, cysl-2, a sulfhydrylase/cysteine synthase in C. elegans, was transcriptionally upregulated by GYY4137 treatment and the deletion of cysl-2 resulted in a significant reduction in lifespan which was partially recovered by the supplementation of GYY4137. Likewise, a mammalian cell culture system, GYY4137 was able to protect bovine aortic endothelial cells (BAECs) from oxidative stress and (H2O2)-induced cell death. Taken together, this provides further support that H2S exerts a protective function which is consistent with the longevity dividend theory. Overall, this study underlines the therapeutic potential of a slow-releasing H2S donor as regulators of the aging and cellular stress pathways.
format	article
author	Bedoor Qabazard Samanza Ahmed Ling Li Volker M Arlt Philip K Moore Stephen R Stürzenbaum
author_facet	Bedoor Qabazard Samanza Ahmed Ling Li Volker M Arlt Philip K Moore Stephen R Stürzenbaum
author_sort	Bedoor Qabazard
title	C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
title_short	C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
title_full	C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
title_fullStr	C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
title_full_unstemmed	C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
title_sort	c. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a9489aeae4c74d0eaa9292ce1d843418
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C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase/cysteine synthase cysl-2.

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