Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

Abstract While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report ou...

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Autores principales:	Jian Ju, Wei Liu, Clint Michael Perlaki, Keren Chen, Chunhua Feng, Quan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a94b50660f3d4f18a6eb687ebac4ac7d
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spelling	oai:doaj.org-article:a94b50660f3d4f18a6eb687ebac4ac7d2021-12-02T16:06:28ZSustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing10.1038/s41598-017-07186-92045-2322https://doaj.org/article/a94b50660f3d4f18a6eb687ebac4ac7d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07186-9https://doaj.org/toc/2045-2322Abstract While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt towards SERS based field biosensing, involving the development of a novel sustained and cost-effective substrate composed of silver nanoparticles protected by small nitrogen-doped Graphene Quantum Dots, i.e. Ag NP@N-GQD, and its systematic evaluation for glucose sensing. The new substrate demonstrated significantly stronger Raman enhancement compared to pure silver nanoparticles. More importantly, the new substrate preserved SERS performance in a normal indoor environment for at least 30 days in both the wet and dry states, in contrast to only 10 days for pure silver nanoparticles. The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. These results suggest that the Ag NP@N-GQD is a cost-effective and sustained SERS substrate, the development of which represents an important step towards SERS based field biosensing.Jian JuWei LiuClint Michael PerlakiKeren ChenChunhua FengQuan LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Ju Wei Liu Clint Michael Perlaki Keren Chen Chunhua Feng Quan Liu Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
description	Abstract While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt towards SERS based field biosensing, involving the development of a novel sustained and cost-effective substrate composed of silver nanoparticles protected by small nitrogen-doped Graphene Quantum Dots, i.e. Ag NP@N-GQD, and its systematic evaluation for glucose sensing. The new substrate demonstrated significantly stronger Raman enhancement compared to pure silver nanoparticles. More importantly, the new substrate preserved SERS performance in a normal indoor environment for at least 30 days in both the wet and dry states, in contrast to only 10 days for pure silver nanoparticles. The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. These results suggest that the Ag NP@N-GQD is a cost-effective and sustained SERS substrate, the development of which represents an important step towards SERS based field biosensing.
format	article
author	Jian Ju Wei Liu Clint Michael Perlaki Keren Chen Chunhua Feng Quan Liu
author_facet	Jian Ju Wei Liu Clint Michael Perlaki Keren Chen Chunhua Feng Quan Liu
author_sort	Jian Ju
title	Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
title_short	Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
title_full	Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
title_fullStr	Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
title_full_unstemmed	Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing
title_sort	sustained and cost effective silver substrate for surface enhanced raman spectroscopy based biosensing
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a94b50660f3d4f18a6eb687ebac4ac7d
work_keys_str_mv	AT jianju sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing AT weiliu sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing AT clintmichaelperlaki sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing AT kerenchen sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing AT chunhuafeng sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing AT quanliu sustainedandcosteffectivesilversubstrateforsurfaceenhancedramanspectroscopybasedbiosensing
_version_	1718384981739307008

Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

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