The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeostasis in mouse intestine, partly through destabil...

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Autores principales: Chloé Maurizy, Claire Abeza, Bénédicte Lemmers, Monica Gabola, Ciro Longobardi, Valérie Pinet, Marina Ferrand, Conception Paul, Julie Bremond, Francina Langa, François Gerbe, Philippe Jay, Céline Verheggen, Nicola Tinari, Dominique Helmlinger, Rossano Lattanzio, Edouard Bertrand, Michael Hahne, Bérengère Pradet-Balade
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/a94c9c9c3f30427b974454354a00e279
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spelling oai:doaj.org-article:a94c9c9c3f30427b974454354a00e2792021-12-02T15:08:12ZThe HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium10.1038/s41467-021-24792-42041-1723https://doaj.org/article/a94c9c9c3f30427b974454354a00e2792021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24792-4https://doaj.org/toc/2041-1723RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeostasis in mouse intestine, partly through destabilization of PI3K-like kinases, while elevated RPAP3 levels in colorectal tumors are associated with poor prognosis.Chloé MaurizyClaire AbezaBénédicte LemmersMonica GabolaCiro LongobardiValérie PinetMarina FerrandConception PaulJulie BremondFrancina LangaFrançois GerbePhilippe JayCéline VerheggenNicola TinariDominique HelmlingerRossano LattanzioEdouard BertrandMichael HahneBérengère Pradet-BaladeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Chloé Maurizy
Claire Abeza
Bénédicte Lemmers
Monica Gabola
Ciro Longobardi
Valérie Pinet
Marina Ferrand
Conception Paul
Julie Bremond
Francina Langa
François Gerbe
Philippe Jay
Céline Verheggen
Nicola Tinari
Dominique Helmlinger
Rossano Lattanzio
Edouard Bertrand
Michael Hahne
Bérengère Pradet-Balade
The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
description RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeostasis in mouse intestine, partly through destabilization of PI3K-like kinases, while elevated RPAP3 levels in colorectal tumors are associated with poor prognosis.
format article
author Chloé Maurizy
Claire Abeza
Bénédicte Lemmers
Monica Gabola
Ciro Longobardi
Valérie Pinet
Marina Ferrand
Conception Paul
Julie Bremond
Francina Langa
François Gerbe
Philippe Jay
Céline Verheggen
Nicola Tinari
Dominique Helmlinger
Rossano Lattanzio
Edouard Bertrand
Michael Hahne
Bérengère Pradet-Balade
author_facet Chloé Maurizy
Claire Abeza
Bénédicte Lemmers
Monica Gabola
Ciro Longobardi
Valérie Pinet
Marina Ferrand
Conception Paul
Julie Bremond
Francina Langa
François Gerbe
Philippe Jay
Céline Verheggen
Nicola Tinari
Dominique Helmlinger
Rossano Lattanzio
Edouard Bertrand
Michael Hahne
Bérengère Pradet-Balade
author_sort Chloé Maurizy
title The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
title_short The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
title_full The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
title_fullStr The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
title_full_unstemmed The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium
title_sort hsp90/r2tp assembly chaperone promotes cell proliferation in the intestinal epithelium
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/a94c9c9c3f30427b974454354a00e279
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