Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations

Abstract Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-can...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xinjun Li, Kristina Sundquist, Jan Sundquist, Asta Försti, Kari Hemminki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a94e31723bc8465187c0179100ea098f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a94e31723bc8465187c0179100ea098f
record_format	dspace
spelling	oai:doaj.org-article:a94e31723bc8465187c0179100ea098f2021-12-02T17:47:15ZFamily history of early onset acute lymphoblastic leukemia is suggesting genetic associations10.1038/s41598-021-90542-72045-2322https://doaj.org/article/a94e31723bc8465187c0179100ea098f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90542-7https://doaj.org/toc/2045-2322Abstract Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until year 2016 to calculate standardized incidence ratios (SIRs) for familial risks in ALL in three diagnostic age-groups: 0–4, 5–34 and 35 + years. Among 1335 ALL patients diagnosed before age 5, familial risks were increased for esophageal (4.78), breast (1.42), prostate (1.40) and connective tissue (2.97) cancers and leukemia (2.51, ALL 7.81). In age-group 5–34 years, rectal (1.73) and endometrial (2.40) cancer, myeloma (2.25) and leukemia (2.00, ALL 4.60) reached statistical significance. In the oldest age-group, the only association was with Hodgkin lymphoma (3.42). Diagnostic ages of family members of ALL patients were significantly lower compared to these cancers in the population for breast, prostate and rectal cancers. The patterns of increased familial cancers suggest that BRCA2 mutations could contribute to associations of ALL with breast and prostate cancers, and mismatch gene PMS2 mutations with rectal and endometrial cancers. Future DNA sequencing data will be a test for these familial predictions.Xinjun LiKristina SundquistJan SundquistAsta FörstiKari HemminkiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xinjun Li Kristina Sundquist Jan Sundquist Asta Försti Kari Hemminki Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
description	Abstract Childhood acute lymphoblastic leukemia (ALL) has an origin in the fetal period which may distinguish it from ALL diagnosed later in life. We wanted to test whether familial risks differ in ALL diagnosed in the very early childhood from ALL diagnosed later. The Swedish nation-wide family-cancer data were used until year 2016 to calculate standardized incidence ratios (SIRs) for familial risks in ALL in three diagnostic age-groups: 0–4, 5–34 and 35 + years. Among 1335 ALL patients diagnosed before age 5, familial risks were increased for esophageal (4.78), breast (1.42), prostate (1.40) and connective tissue (2.97) cancers and leukemia (2.51, ALL 7.81). In age-group 5–34 years, rectal (1.73) and endometrial (2.40) cancer, myeloma (2.25) and leukemia (2.00, ALL 4.60) reached statistical significance. In the oldest age-group, the only association was with Hodgkin lymphoma (3.42). Diagnostic ages of family members of ALL patients were significantly lower compared to these cancers in the population for breast, prostate and rectal cancers. The patterns of increased familial cancers suggest that BRCA2 mutations could contribute to associations of ALL with breast and prostate cancers, and mismatch gene PMS2 mutations with rectal and endometrial cancers. Future DNA sequencing data will be a test for these familial predictions.
format	article
author	Xinjun Li Kristina Sundquist Jan Sundquist Asta Försti Kari Hemminki
author_facet	Xinjun Li Kristina Sundquist Jan Sundquist Asta Försti Kari Hemminki
author_sort	Xinjun Li
title	Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
title_short	Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
title_full	Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
title_fullStr	Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
title_full_unstemmed	Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
title_sort	family history of early onset acute lymphoblastic leukemia is suggesting genetic associations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a94e31723bc8465187c0179100ea098f
work_keys_str_mv	AT xinjunli familyhistoryofearlyonsetacutelymphoblasticleukemiaissuggestinggeneticassociations AT kristinasundquist familyhistoryofearlyonsetacutelymphoblasticleukemiaissuggestinggeneticassociations AT jansundquist familyhistoryofearlyonsetacutelymphoblasticleukemiaissuggestinggeneticassociations AT astaforsti familyhistoryofearlyonsetacutelymphoblasticleukemiaissuggestinggeneticassociations AT karihemminki familyhistoryofearlyonsetacutelymphoblasticleukemiaissuggestinggeneticassociations
_version_	1718379487833358336

Family history of early onset acute lymphoblastic leukemia is suggesting genetic associations

Ejemplares similares