Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?

Background: Cytokeratin 19-positive (CK19(+)) hepatocellular carcinomas (HCC) are generally associated with poor prognosis after hepatectomy. It is typically detected from postoperative immunochemistry. We have analyzed several clinically available biomarkers, in particular, neutrophil to lymphocyte...

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Autores principales:	Chao-Wei Lee, Sey-En Lin, Ming-Chin Yu, Hao-Wei Kou, Cheng-Han Lee, Tony Kuo, Kuan-Chieh Lee, Hsin-I Tsai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neutrophil to lymphocyte ratio NLR hepatocellular carcinoma hepatoma cytokeratin 19 (CK19) Medicine R
Acceso en línea:	https://doaj.org/article/a95080fe17b74e3cad83ec35b9eacc90
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spelling	oai:doaj.org-article:a95080fe17b74e3cad83ec35b9eacc902021-11-25T18:06:57ZDoes Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?10.3390/jpm111110782075-4426https://doaj.org/article/a95080fe17b74e3cad83ec35b9eacc902021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1078https://doaj.org/toc/2075-4426Background: Cytokeratin 19-positive (CK19(+)) hepatocellular carcinomas (HCC) are generally associated with poor prognosis after hepatectomy. It is typically detected from postoperative immunochemistry. We have analyzed several clinically available biomarkers, in particular, neutrophil to lymphocyte ratio (NLR) and aim to develop a panel of biomarkers in identifying CK19 expression in (HCC) preoperatively. Methods: We retrospectively reviewed 36 HCC patients who underwent liver resections during January 2017 to March 2018 in Chang Gung Memorial Hospital. Patients were grouped based on the status of CK19 expression and their baseline characteristics, perioperative and oncologic outcomes were compared. Novel biomarkers including NLR, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and uric acid were analyzed and correlated with CK19 expression. Results: NLR is highly associated with CK19 expression. NLR alone gave an AUROC of 0.728 (<i>p</i>-value = 0.043), higher than AFP, CEA or tumor size alone. NLR when combined with AFP, CEA and uric acid, gave an AUROC as high as 0.933 (<i>p</i>-value = 0.004). Conclusion: The current study demonstrated the predictive capability of NLR in combination with AFP, CEA and uric acid for CK19 expression in HCC patients preoperatively. Further prospective, large-scale studies are warranted to validate our findings.Chao-Wei LeeSey-En LinMing-Chin YuHao-Wei KouCheng-Han LeeTony KuoKuan-Chieh LeeHsin-I TsaiMDPI AGarticleneutrophil to lymphocyte ratioNLRhepatocellular carcinomahepatomacytokeratin 19 (CK19)MedicineRENJournal of Personalized Medicine, Vol 11, Iss 1078, p 1078 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neutrophil to lymphocyte ratio NLR hepatocellular carcinoma hepatoma cytokeratin 19 (CK19) Medicine R
spellingShingle	neutrophil to lymphocyte ratio NLR hepatocellular carcinoma hepatoma cytokeratin 19 (CK19) Medicine R Chao-Wei Lee Sey-En Lin Ming-Chin Yu Hao-Wei Kou Cheng-Han Lee Tony Kuo Kuan-Chieh Lee Hsin-I Tsai Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
description	Background: Cytokeratin 19-positive (CK19(+)) hepatocellular carcinomas (HCC) are generally associated with poor prognosis after hepatectomy. It is typically detected from postoperative immunochemistry. We have analyzed several clinically available biomarkers, in particular, neutrophil to lymphocyte ratio (NLR) and aim to develop a panel of biomarkers in identifying CK19 expression in (HCC) preoperatively. Methods: We retrospectively reviewed 36 HCC patients who underwent liver resections during January 2017 to March 2018 in Chang Gung Memorial Hospital. Patients were grouped based on the status of CK19 expression and their baseline characteristics, perioperative and oncologic outcomes were compared. Novel biomarkers including NLR, alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and uric acid were analyzed and correlated with CK19 expression. Results: NLR is highly associated with CK19 expression. NLR alone gave an AUROC of 0.728 (<i>p</i>-value = 0.043), higher than AFP, CEA or tumor size alone. NLR when combined with AFP, CEA and uric acid, gave an AUROC as high as 0.933 (<i>p</i>-value = 0.004). Conclusion: The current study demonstrated the predictive capability of NLR in combination with AFP, CEA and uric acid for CK19 expression in HCC patients preoperatively. Further prospective, large-scale studies are warranted to validate our findings.
format	article
author	Chao-Wei Lee Sey-En Lin Ming-Chin Yu Hao-Wei Kou Cheng-Han Lee Tony Kuo Kuan-Chieh Lee Hsin-I Tsai
author_facet	Chao-Wei Lee Sey-En Lin Ming-Chin Yu Hao-Wei Kou Cheng-Han Lee Tony Kuo Kuan-Chieh Lee Hsin-I Tsai
author_sort	Chao-Wei Lee
title	Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
title_short	Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
title_full	Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
title_fullStr	Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
title_full_unstemmed	Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?
title_sort	does neutrophil to lymphocyte ratio have a role in identifying cytokeratin 19-expressing hepatocellular carcinoma?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a95080fe17b74e3cad83ec35b9eacc90
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Does Neutrophil to Lymphocyte Ratio Have a Role in Identifying Cytokeratin 19-Expressing Hepatocellular Carcinoma?

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