Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children

Abstract The genetic susceptibility to and vaccine effectiveness against rotavirus gastroenteritis were different in distinct ethnic groups. The case-control study was aimed to evaluate the effectiveness of rotavirus vaccines and associations between the histo-blood group antigens and susceptibility...

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Autores principales: Ting-An Yang, Ju-Yin Hou, Yhu-Chering Huang, Chih-Jung Chen
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/a9513e31ba454029977f052f15bd7d3d
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spelling oai:doaj.org-article:a9513e31ba454029977f052f15bd7d3d2021-12-02T15:05:48ZGenetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children10.1038/s41598-017-06686-y2045-2322https://doaj.org/article/a9513e31ba454029977f052f15bd7d3d2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06686-yhttps://doaj.org/toc/2045-2322Abstract The genetic susceptibility to and vaccine effectiveness against rotavirus gastroenteritis were different in distinct ethnic groups. The case-control study was aimed to evaluate the effectiveness of rotavirus vaccines and associations between the histo-blood group antigens and susceptibility to rotavirus infections in a Taiwanese population. Cases were children <18 years old who were hospitalized because of laboratory-confirmed rotavirus infection. Controls were healthy children matched to cases by age and gender. The secretor status and Lewis antigen and ABO types were determined by molecular methods. A total of 68 cases and 133 controls were included. Rotavirus immunization was recorded in 8 (12%) cases and 77 (58%) controls, indicating a vaccine effectiveness of 90.3% (95% confidence interval [CI], 78.1% − 95.7%). The secretor and Lewis-positive genotypes were independently associated with increased risk of rotavirus infections (matched odds ratio [mOR] 28.5, 95% CI 2.94–277, P = 0.003 and mOR 16.8, 95% CI 1.08–2601, P = 0.04, respectively). The distribution of ABO blood types did not differ significantly between cases and controls (P = 0.47). In conclusion, Taiwanese children with the secretor genotype and Lewis-positive genotype were at increased risk of moderate-to-severe rotavirus infections. The illness can be effectively prevented by immunization in this population.Ting-An YangJu-Yin HouYhu-Chering HuangChih-Jung ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Ting-An Yang
Ju-Yin Hou
Yhu-Chering Huang
Chih-Jung Chen
Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
description Abstract The genetic susceptibility to and vaccine effectiveness against rotavirus gastroenteritis were different in distinct ethnic groups. The case-control study was aimed to evaluate the effectiveness of rotavirus vaccines and associations between the histo-blood group antigens and susceptibility to rotavirus infections in a Taiwanese population. Cases were children <18 years old who were hospitalized because of laboratory-confirmed rotavirus infection. Controls were healthy children matched to cases by age and gender. The secretor status and Lewis antigen and ABO types were determined by molecular methods. A total of 68 cases and 133 controls were included. Rotavirus immunization was recorded in 8 (12%) cases and 77 (58%) controls, indicating a vaccine effectiveness of 90.3% (95% confidence interval [CI], 78.1% − 95.7%). The secretor and Lewis-positive genotypes were independently associated with increased risk of rotavirus infections (matched odds ratio [mOR] 28.5, 95% CI 2.94–277, P = 0.003 and mOR 16.8, 95% CI 1.08–2601, P = 0.04, respectively). The distribution of ABO blood types did not differ significantly between cases and controls (P = 0.47). In conclusion, Taiwanese children with the secretor genotype and Lewis-positive genotype were at increased risk of moderate-to-severe rotavirus infections. The illness can be effectively prevented by immunization in this population.
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author Ting-An Yang
Ju-Yin Hou
Yhu-Chering Huang
Chih-Jung Chen
author_facet Ting-An Yang
Ju-Yin Hou
Yhu-Chering Huang
Chih-Jung Chen
author_sort Ting-An Yang
title Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
title_short Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
title_full Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
title_fullStr Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
title_full_unstemmed Genetic Susceptibility to Rotavirus Gastroenteritis and Vaccine Effectiveness in Taiwanese Children
title_sort genetic susceptibility to rotavirus gastroenteritis and vaccine effectiveness in taiwanese children
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a9513e31ba454029977f052f15bd7d3d
work_keys_str_mv AT tinganyang geneticsusceptibilitytorotavirusgastroenteritisandvaccineeffectivenessintaiwanesechildren
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AT yhucheringhuang geneticsusceptibilitytorotavirusgastroenteritisandvaccineeffectivenessintaiwanesechildren
AT chihjungchen geneticsusceptibilitytorotavirusgastroenteritisandvaccineeffectivenessintaiwanesechildren
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