Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study

Patients in intensive care units (ICUs) are at high risk of drug–drug interactions (DDIs) due to polypharmacy. Little is known about type and frequency of DDIs within German ICUs. Clinical pharmacists’ interventions (PI) recorded in a national database (ADKA-DokuPIK) were filtered for ICU patients....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Joachim Andreas Koeck, Heike Hilgarth, Andreas von Ameln-Mayerhofer, Damaris Meyn, Ruediger Warlich, Andreas Münstedt, Dagmar Horn, Christina König
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	drug–drug interactions clinical pharmacy intensive care unit critical care pharmacist Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a954d48872ce4c0a83e722015168be25
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a954d48872ce4c0a83e722015168be25
record_format	dspace
spelling	oai:doaj.org-article:a954d48872ce4c0a83e722015168be252021-11-25T16:22:55ZClinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study10.3390/antibiotics101113302079-6382https://doaj.org/article/a954d48872ce4c0a83e722015168be252021-10-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1330https://doaj.org/toc/2079-6382Patients in intensive care units (ICUs) are at high risk of drug–drug interactions (DDIs) due to polypharmacy. Little is known about type and frequency of DDIs within German ICUs. Clinical pharmacists’ interventions (PI) recorded in a national database (ADKA-DokuPIK) were filtered for ICU patients. Binary DDIs involving ≥1 anti-infective agent with >1 database entry were selected. A modified two-step Delphi process with a group of senior hospital pharmacists was employed to evaluate selected DDIs for clinical relevance by using a five-point scale and to develop guidance for clinical practice. In total, 16,173 PI were recorded, including 1836 (11%) DDIs in the ICU setting. Of the latter, 41% (756/1836) included ≥1 anti-infective agent, 32% (590/1836) were binary DDIs, and 25% (455/1836) were listed at least twice. This translates into 88 different DDIs, 74% (65/88) of which were rated as being clinically relevant by our expert panel. The majority of DDIs (76% [67/88]) included macrolides, antifungals, or fluoroquinolones. This percentage was even higher in DDIs being rated as clinically relevant by the experts (85% [55/65]). It is noted that an inter-professional discussion and approach is needed in the individual patient management of DDIs. The guidance developed might be a tool for decision support.Joachim Andreas KoeckHeike HilgarthAndreas von Ameln-MayerhoferDamaris MeynRuediger WarlichAndreas MünstedtDagmar HornChristina KönigMDPI AGarticledrug–drug interactionsclinical pharmacyintensive care unitcritical care pharmacistTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1330, p 1330 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug–drug interactions clinical pharmacy intensive care unit critical care pharmacist Therapeutics. Pharmacology RM1-950
spellingShingle	drug–drug interactions clinical pharmacy intensive care unit critical care pharmacist Therapeutics. Pharmacology RM1-950 Joachim Andreas Koeck Heike Hilgarth Andreas von Ameln-Mayerhofer Damaris Meyn Ruediger Warlich Andreas Münstedt Dagmar Horn Christina König Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
description	Patients in intensive care units (ICUs) are at high risk of drug–drug interactions (DDIs) due to polypharmacy. Little is known about type and frequency of DDIs within German ICUs. Clinical pharmacists’ interventions (PI) recorded in a national database (ADKA-DokuPIK) were filtered for ICU patients. Binary DDIs involving ≥1 anti-infective agent with >1 database entry were selected. A modified two-step Delphi process with a group of senior hospital pharmacists was employed to evaluate selected DDIs for clinical relevance by using a five-point scale and to develop guidance for clinical practice. In total, 16,173 PI were recorded, including 1836 (11%) DDIs in the ICU setting. Of the latter, 41% (756/1836) included ≥1 anti-infective agent, 32% (590/1836) were binary DDIs, and 25% (455/1836) were listed at least twice. This translates into 88 different DDIs, 74% (65/88) of which were rated as being clinically relevant by our expert panel. The majority of DDIs (76% [67/88]) included macrolides, antifungals, or fluoroquinolones. This percentage was even higher in DDIs being rated as clinically relevant by the experts (85% [55/65]). It is noted that an inter-professional discussion and approach is needed in the individual patient management of DDIs. The guidance developed might be a tool for decision support.
format	article
author	Joachim Andreas Koeck Heike Hilgarth Andreas von Ameln-Mayerhofer Damaris Meyn Ruediger Warlich Andreas Münstedt Dagmar Horn Christina König
author_facet	Joachim Andreas Koeck Heike Hilgarth Andreas von Ameln-Mayerhofer Damaris Meyn Ruediger Warlich Andreas Münstedt Dagmar Horn Christina König
author_sort	Joachim Andreas Koeck
title	Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
title_short	Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
title_full	Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
title_fullStr	Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
title_full_unstemmed	Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study
title_sort	clinically relevant interactions with anti-infectives on intensive care units—a multicenter delphi study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a954d48872ce4c0a83e722015168be25
work_keys_str_mv	AT joachimandreaskoeck clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT heikehilgarth clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT andreasvonamelnmayerhofer clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT damarismeyn clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT ruedigerwarlich clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT andreasmunstedt clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT dagmarhorn clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy AT christinakonig clinicallyrelevantinteractionswithantiinfectivesonintensivecareunitsamulticenterdelphistudy
_version_	1718413218498478080

Clinically Relevant Interactions with Anti-Infectives on Intensive Care Units—A Multicenter Delphi Study

Ejemplares similares