The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1

Abstract iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively....

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Autores principales: Puspa Thapa, Bryce Manso, Ji Young Chung, Sinibaldo Romera Arocha, Hai-Hui Xue, Derek B. Sant’ Angelo, Virginia Smith Shapiro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/a955fde430764952a7afc41f1001ca19
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