Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq

MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.

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Autores principales: Silvia Bottini, Nedra Hamouda-Tekaya, Raphael Mategot, Laure-Emmanuelle Zaragosi, Stephane Audebert, Sabrina Pisano, Valerie Grandjean, Claire Mauduit, Mohamed Benahmed, Pascal Barbry, Emanuela Repetto, Michele Trabucchi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/a9569527816747cead945fe23c5ab98f
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spelling oai:doaj.org-article:a9569527816747cead945fe23c5ab98f2021-12-02T15:38:57ZPost-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq10.1038/s41467-017-01126-x2041-1723https://doaj.org/article/a9569527816747cead945fe23c5ab98f2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01126-xhttps://doaj.org/toc/2041-1723MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.Silvia BottiniNedra Hamouda-TekayaRaphael MategotLaure-Emmanuelle ZaragosiStephane AudebertSabrina PisanoValerie GrandjeanClaire MauduitMohamed BenahmedPascal BarbryEmanuela RepettoMichele TrabucchiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Silvia Bottini
Nedra Hamouda-Tekaya
Raphael Mategot
Laure-Emmanuelle Zaragosi
Stephane Audebert
Sabrina Pisano
Valerie Grandjean
Claire Mauduit
Mohamed Benahmed
Pascal Barbry
Emanuela Repetto
Michele Trabucchi
Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
description MicroRNAs have been best characterized for their functions in the cytoplasm; however, there is growing evidence of a nuclear localized role. Here, the authors identify Sfpq as an Ago2-interacting protein that modulates miRNA activity in both the nucleus and cytoplasm.
format article
author Silvia Bottini
Nedra Hamouda-Tekaya
Raphael Mategot
Laure-Emmanuelle Zaragosi
Stephane Audebert
Sabrina Pisano
Valerie Grandjean
Claire Mauduit
Mohamed Benahmed
Pascal Barbry
Emanuela Repetto
Michele Trabucchi
author_facet Silvia Bottini
Nedra Hamouda-Tekaya
Raphael Mategot
Laure-Emmanuelle Zaragosi
Stephane Audebert
Sabrina Pisano
Valerie Grandjean
Claire Mauduit
Mohamed Benahmed
Pascal Barbry
Emanuela Repetto
Michele Trabucchi
author_sort Silvia Bottini
title Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
title_short Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
title_full Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
title_fullStr Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
title_full_unstemmed Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq
title_sort post-transcriptional gene silencing mediated by micrornas is controlled by nucleoplasmic sfpq
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/a9569527816747cead945fe23c5ab98f
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