Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

Abstract Maternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated the impact of maternal tobacco exposure on their offspring’s HC...

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Autores principales:	Tadashi Shiohama, Aya Hisada, Midori Yamamoto, Kenichi Sakurai, Rieko Takatani, Katsunori Fujii, Naoki Shimojo, Chisato Mori, the Japan Environment Children’s Study (JECS) Group
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a95c057c956a425eb64f2749f33bdd58
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spelling	oai:doaj.org-article:a95c057c956a425eb64f2749f33bdd582021-12-02T15:14:47ZDecreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study10.1038/s41598-021-98311-22045-2322https://doaj.org/article/a95c057c956a425eb64f2749f33bdd582021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98311-2https://doaj.org/toc/2045-2322Abstract Maternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated the impact of maternal tobacco exposure on their offspring’s HC and the relationship with placental weight ratio (PWR) and placental abnormalities. Parents-children pairs (n = 84,856) were included from the 104,065 records of the Japan Environmental and Children’s Study. Maternal perinatal clinical and social information by self-administered questionnaires, offspring’s body size, and placental information were collected. Data were analyzed with binominal logistic regression analysis and path analysis. Logistic regression showed significantly elevated adjusted odds ratio (aOR) (1.653, 95% CI 1.387–1.969) for the impact of maternal smoking during pregnancy on their offspring’s smaller HC at birth. Maternal exposure to environmental tobacco smoke in the non-smoking group did not increase aOR for the smaller HC. Path analysis showed that maternal smoking during pregnancy decreased the offspring’s HC directly, but not indirectly via PWR or placental abnormalities. The quitting smoking during pregnancy group did not increase aOR for the smaller HC than the non-smoking group, suggesting that quitting smoking may reduce their offspring’s neurological impairment even after pregnancy.Tadashi ShiohamaAya HisadaMidori YamamotoKenichi SakuraiRieko TakataniKatsunori FujiiNaoki ShimojoChisato Morithe Japan Environment Children’s Study (JECS) GroupNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tadashi Shiohama Aya Hisada Midori Yamamoto Kenichi Sakurai Rieko Takatani Katsunori Fujii Naoki Shimojo Chisato Mori the Japan Environment Children’s Study (JECS) Group Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
description	Abstract Maternal tobacco smoke exposure during pregnancy impairs fetal body size, including head circumference (HC) at birth; however, the mechanism still remains unclear. This analysis using a large prospective cohort study evaluated the impact of maternal tobacco exposure on their offspring’s HC and the relationship with placental weight ratio (PWR) and placental abnormalities. Parents-children pairs (n = 84,856) were included from the 104,065 records of the Japan Environmental and Children’s Study. Maternal perinatal clinical and social information by self-administered questionnaires, offspring’s body size, and placental information were collected. Data were analyzed with binominal logistic regression analysis and path analysis. Logistic regression showed significantly elevated adjusted odds ratio (aOR) (1.653, 95% CI 1.387–1.969) for the impact of maternal smoking during pregnancy on their offspring’s smaller HC at birth. Maternal exposure to environmental tobacco smoke in the non-smoking group did not increase aOR for the smaller HC. Path analysis showed that maternal smoking during pregnancy decreased the offspring’s HC directly, but not indirectly via PWR or placental abnormalities. The quitting smoking during pregnancy group did not increase aOR for the smaller HC than the non-smoking group, suggesting that quitting smoking may reduce their offspring’s neurological impairment even after pregnancy.
format	article
author	Tadashi Shiohama Aya Hisada Midori Yamamoto Kenichi Sakurai Rieko Takatani Katsunori Fujii Naoki Shimojo Chisato Mori the Japan Environment Children’s Study (JECS) Group
author_facet	Tadashi Shiohama Aya Hisada Midori Yamamoto Kenichi Sakurai Rieko Takatani Katsunori Fujii Naoki Shimojo Chisato Mori the Japan Environment Children’s Study (JECS) Group
author_sort	Tadashi Shiohama
title	Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
title_short	Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
title_full	Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
title_fullStr	Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
title_full_unstemmed	Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study
title_sort	decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the japanese prospective birth cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a95c057c956a425eb64f2749f33bdd58
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Decreased head circumference at birth associated with maternal tobacco smoke exposure during pregnancy on the Japanese prospective birth cohort study

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