More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles...

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Autores principales:	Sandra Lopez-Leon, Talia Wegman-Ostrosky, Carol Perelman, Rosalinda Sepulveda, Paulina A. Rebolledo, Angelica Cuapio, Sonia Villapol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a95d3bacbec94dd0967b917fedd0dc79
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spelling	oai:doaj.org-article:a95d3bacbec94dd0967b917fedd0dc792021-12-02T18:50:59ZMore than 50 long-term effects of COVID-19: a systematic review and meta-analysis10.1038/s41598-021-95565-82045-2322https://doaj.org/article/a95d3bacbec94dd0967b917fedd0dc792021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95565-8https://doaj.org/toc/2045-2322Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.Sandra Lopez-LeonTalia Wegman-OstroskyCarol PerelmanRosalinda SepulvedaPaulina A. RebolledoAngelica CuapioSonia VillapolNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sandra Lopez-Leon Talia Wegman-Ostrosky Carol Perelman Rosalinda Sepulveda Paulina A. Rebolledo Angelica Cuapio Sonia Villapol More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
description	Abstract COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.
format	article
author	Sandra Lopez-Leon Talia Wegman-Ostrosky Carol Perelman Rosalinda Sepulveda Paulina A. Rebolledo Angelica Cuapio Sonia Villapol
author_facet	Sandra Lopez-Leon Talia Wegman-Ostrosky Carol Perelman Rosalinda Sepulveda Paulina A. Rebolledo Angelica Cuapio Sonia Villapol
author_sort	Sandra Lopez-Leon
title	More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
title_short	More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
title_full	More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
title_fullStr	More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
title_full_unstemmed	More than 50 long-term effects of COVID-19: a systematic review and meta-analysis
title_sort	more than 50 long-term effects of covid-19: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a95d3bacbec94dd0967b917fedd0dc79
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More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

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