Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.

Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binar...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alexander Varzari, Vladimir Kharkov, Alexey G Nikitin, Florina Raicu, Kseniya Simonova, Wolfgang Stephan, Elisabeth H Weiss, Vadim Stepanov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a9633da239564561a5cfcdf54d66b4d0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a9633da239564561a5cfcdf54d66b4d0
record_format	dspace
spelling	oai:doaj.org-article:a9633da239564561a5cfcdf54d66b4d02021-11-18T08:01:16ZPaleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.1932-620310.1371/journal.pone.0053731https://doaj.org/article/a9633da239564561a5cfcdf54d66b4d02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23341985/?tool=EBIhttps://doaj.org/toc/1932-6203Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binary and 17 multiallelic (STRs) polymorphisms on the non-recombining portion of the Y chromosome in 125 Moldavian males. In addition, 53 Ukrainians from eastern Moldova and 54 Romanians from the neighboring eastern Romania were typed using the same set of markers. In Moldavians, 19 Y chromosome haplogroups were identified, the most common being I-M423 (20.8%), R-M17* (17.6%), R-M458 (12.8%), E-v13 (8.8%), R-M269* and R-M412* (both 7.2%). In Romanians, 14 haplogroups were found including I-M423 (40.7%), R-M17* (16.7%), R-M405 (7.4%), E-v13 and R-M412* (both 5.6%). In Ukrainians, 13 haplogroups were identified including R-M17 (34.0%), I-M423 (20.8%), R-M269* (9.4%), N-M178, R-M458 and R-M73 (each 5.7%). Our results show that a significant majority of the Moldavian paternal gene pool belongs to eastern/central European and Balkan/eastern Mediterranean Y lineages. Phylogenetic and AMOVA analyses based on Y-STR loci also revealed that Moldavians are close to both eastern/central European and Balkan-Carpathian populations. The data correlate well with historical accounts and geographical location of the region and thus allow to hypothesize that extant Moldavian paternal genetic lineages arose from extensive recent admixture between genetically autochthonous populations of the Balkan-Carpathian zone and neighboring Slavic groups.Alexander VarzariVladimir KharkovAlexey G NikitinFlorina RaicuKseniya SimonovaWolfgang StephanElisabeth H WeissVadim StepanovPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53731 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Varzari Vladimir Kharkov Alexey G Nikitin Florina Raicu Kseniya Simonova Wolfgang Stephan Elisabeth H Weiss Vadim Stepanov Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
description	Moldova has a rich historical and cultural heritage, which may be reflected in the current genetic makeup of its population. To date, no comprehensive studies exist about the population genetic structure of modern Moldavians. To bridge this gap with respect to paternal lineages, we analyzed 37 binary and 17 multiallelic (STRs) polymorphisms on the non-recombining portion of the Y chromosome in 125 Moldavian males. In addition, 53 Ukrainians from eastern Moldova and 54 Romanians from the neighboring eastern Romania were typed using the same set of markers. In Moldavians, 19 Y chromosome haplogroups were identified, the most common being I-M423 (20.8%), R-M17* (17.6%), R-M458 (12.8%), E-v13 (8.8%), R-M269* and R-M412* (both 7.2%). In Romanians, 14 haplogroups were found including I-M423 (40.7%), R-M17* (16.7%), R-M405 (7.4%), E-v13 and R-M412* (both 5.6%). In Ukrainians, 13 haplogroups were identified including R-M17 (34.0%), I-M423 (20.8%), R-M269* (9.4%), N-M178, R-M458 and R-M73 (each 5.7%). Our results show that a significant majority of the Moldavian paternal gene pool belongs to eastern/central European and Balkan/eastern Mediterranean Y lineages. Phylogenetic and AMOVA analyses based on Y-STR loci also revealed that Moldavians are close to both eastern/central European and Balkan-Carpathian populations. The data correlate well with historical accounts and geographical location of the region and thus allow to hypothesize that extant Moldavian paternal genetic lineages arose from extensive recent admixture between genetically autochthonous populations of the Balkan-Carpathian zone and neighboring Slavic groups.
format	article
author	Alexander Varzari Vladimir Kharkov Alexey G Nikitin Florina Raicu Kseniya Simonova Wolfgang Stephan Elisabeth H Weiss Vadim Stepanov
author_facet	Alexander Varzari Vladimir Kharkov Alexey G Nikitin Florina Raicu Kseniya Simonova Wolfgang Stephan Elisabeth H Weiss Vadim Stepanov
author_sort	Alexander Varzari
title	Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
title_short	Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
title_full	Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
title_fullStr	Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
title_full_unstemmed	Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.
title_sort	paleo-balkan and slavic contributions to the genetic pool of moldavians: insights from the y chromosome.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a9633da239564561a5cfcdf54d66b4d0
work_keys_str_mv	AT alexandervarzari paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT vladimirkharkov paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT alexeygnikitin paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT florinaraicu paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT kseniyasimonova paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT wolfgangstephan paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT elisabethhweiss paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome AT vadimstepanov paleobalkanandslaviccontributionstothegeneticpoolofmoldaviansinsightsfromtheychromosome
_version_	1718422622740414464

Paleo-Balkan and Slavic contributions to the genetic pool of Moldavians: insights from the Y chromosome.

Ejemplares similares