A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2.
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Nature Portfolio
2021
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oai:doaj.org-article:a96a0ab6494b4682a6b6f2fb491288932021-12-02T17:12:24ZA high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry10.1038/s41467-021-24156-y2041-1723https://doaj.org/article/a96a0ab6494b4682a6b6f2fb491288932021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24156-yhttps://doaj.org/toc/2041-1723The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2.Yanwen ChenTravis B. LearJohn W. EvankovichMads B. LarsenBo LinIrene AlfarasJason R. KennerdellLaura SalminenDaniel P. CamarcoKarina C. LockwoodFerhan TuncerJie LiuMichael M. MyerburgJohn F. McDyerYuan LiuToren FinkelBill B. ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| description |
The serine protease TMPRSS2 primes SARS-CoV-2 glycoprotein for cell entry. Here, the authors perform a screen to identify drugs that reduce TMPRSS2 expression and find that halofuginone modulates proteasome-mediated degradation of TMPRSS2 and reduces entry of SARS-CoV-2. |
| format |
article |
| author |
Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen |
| author_facet |
Yanwen Chen Travis B. Lear John W. Evankovich Mads B. Larsen Bo Lin Irene Alfaras Jason R. Kennerdell Laura Salminen Daniel P. Camarco Karina C. Lockwood Ferhan Tuncer Jie Liu Michael M. Myerburg John F. McDyer Yuan Liu Toren Finkel Bill B. Chen |
| author_sort |
Yanwen Chen |
| title |
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_short |
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_full |
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_fullStr |
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_full_unstemmed |
A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry |
| title_sort |
high-throughput screen for tmprss2 expression identifies fda-approved compounds that can limit sars-cov-2 entry |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/a96a0ab6494b4682a6b6f2fb49128893 |
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