Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes

Abstract Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy. Targeted inhibition of these oncogenic receptors however invariably leads to resistance, resulting from acquisition of resistance-inducing...

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Bibliographic Details
Main Authors: Corina N. A. M. van den Heuvel, Arvid I. Das, Tessa de Bitter, Femke Simmer, Thomas Wurdinger, Miguel Angel Molina-Vila, William P. J. Leenders
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/a96e3530439a41b7b9df6a5ba6233936
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