Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019

Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated for the presence of the following viruses: the r...

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Autores principales:	Natalia Golender, Velizar Bumbarov, Anita Kovtunenko, Dan David, Marisol Guini-Rubinstein, Asaf Sol, Martin Beer, Avi Eldar, Kerstin Wernike
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	abortion malformation fetal infection cattle sheep goat Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a96e921d6d534595a90855ac9e39780a
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spelling	oai:doaj.org-article:a96e921d6d534595a90855ac9e39780a2021-11-25T19:12:36ZIdentification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–201910.3390/v131121361999-4915https://doaj.org/article/a96e921d6d534595a90855ac9e39780a2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2136https://doaj.org/toc/1999-4915Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated for the presence of the following viruses: the reoviruses bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV), the flaviviruses bovine viral diarrhea virus (BVDV) and border disease virus (BDV), the peribunyaviruses Shuni virus (SHUV) and Akabane virus (AKAV), bovine herpesvirus type 1 (BoHV-1) and bovine ephemeral fever virus (BEFV). Domestic (cattle, sheep, goat) and wild/zoo ruminants were included in the study. The presence of viral nucleic acid or antigen could be confirmed in 21.8 % of abnormal pregnancies (213 out of 976 investigated cases), with peribunyaviruses, reoviruses and pestiviruses being the most prevalent. At least four different BTV serotypes were involved in abnormal courses of pregnancy in Israel. The subtyping of pestiviruses revealed the presence of two BDV and several distinct BVDV type 1 strains. The peribunyaviruses AKAV and SHUV were identified annually throughout the study period, however, variation in the extent of virus circulation could be observed between the years. In 2018, AKAV even represented the most detected pathogen in cases of small domestic ruminant gestation abnormalities. In conclusion, it was shown that various viruses are involved in abnormal courses of pregnancy in ruminants in Israel.Natalia GolenderVelizar BumbarovAnita KovtunenkoDan DavidMarisol Guini-RubinsteinAsaf SolMartin BeerAvi EldarKerstin WernikeMDPI AGarticleabortionmalformationfetal infectioncattlesheepgoatMicrobiologyQR1-502ENViruses, Vol 13, Iss 2136, p 2136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	abortion malformation fetal infection cattle sheep goat Microbiology QR1-502
spellingShingle	abortion malformation fetal infection cattle sheep goat Microbiology QR1-502 Natalia Golender Velizar Bumbarov Anita Kovtunenko Dan David Marisol Guini-Rubinstein Asaf Sol Martin Beer Avi Eldar Kerstin Wernike Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
description	Infectious agents including viruses are important abortifacients and can cause fetal abnormalities in livestock animals. Here, samples that had been collected in Israel from aborted or malformed ruminant fetuses between 2015 and 2019 were investigated for the presence of the following viruses: the reoviruses bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV), the flaviviruses bovine viral diarrhea virus (BVDV) and border disease virus (BDV), the peribunyaviruses Shuni virus (SHUV) and Akabane virus (AKAV), bovine herpesvirus type 1 (BoHV-1) and bovine ephemeral fever virus (BEFV). Domestic (cattle, sheep, goat) and wild/zoo ruminants were included in the study. The presence of viral nucleic acid or antigen could be confirmed in 21.8 % of abnormal pregnancies (213 out of 976 investigated cases), with peribunyaviruses, reoviruses and pestiviruses being the most prevalent. At least four different BTV serotypes were involved in abnormal courses of pregnancy in Israel. The subtyping of pestiviruses revealed the presence of two BDV and several distinct BVDV type 1 strains. The peribunyaviruses AKAV and SHUV were identified annually throughout the study period, however, variation in the extent of virus circulation could be observed between the years. In 2018, AKAV even represented the most detected pathogen in cases of small domestic ruminant gestation abnormalities. In conclusion, it was shown that various viruses are involved in abnormal courses of pregnancy in ruminants in Israel.
format	article
author	Natalia Golender Velizar Bumbarov Anita Kovtunenko Dan David Marisol Guini-Rubinstein Asaf Sol Martin Beer Avi Eldar Kerstin Wernike
author_facet	Natalia Golender Velizar Bumbarov Anita Kovtunenko Dan David Marisol Guini-Rubinstein Asaf Sol Martin Beer Avi Eldar Kerstin Wernike
author_sort	Natalia Golender
title	Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
title_short	Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
title_full	Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
title_fullStr	Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
title_full_unstemmed	Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019
title_sort	identification and genetic characterization of viral pathogens in ruminant gestation abnormalities, israel, 2015–2019
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a96e921d6d534595a90855ac9e39780a
work_keys_str_mv	AT nataliagolender identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT velizarbumbarov identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT anitakovtunenko identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT dandavid identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT marisolguinirubinstein identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT asafsol identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT martinbeer identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT avieldar identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019 AT kerstinwernike identificationandgeneticcharacterizationofviralpathogensinruminantgestationabnormalitiesisrael20152019
_version_	1718410175226839040

Identification and Genetic Characterization of Viral Pathogens in Ruminant Gestation Abnormalities, Israel, 2015–2019

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