NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D c...

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Autores principales:	Priscillia Lhoumaud, Sana Badri, Javier Rodriguez-Hernaez, Theodore Sakellaropoulos, Gunjan Sethia, Andreas Kloetgen, MacIntosh Cornwell, Sourya Bhattacharyya, Ferhat Ay, Richard Bonneau, Aristotelis Tsirigos, Jane A. Skok
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9714ab2ecf84d2fb21b384d6ebd3d76
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spelling	oai:doaj.org-article:a9714ab2ecf84d2fb21b384d6ebd3d762021-12-02T15:36:21ZNSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains10.1038/s41467-019-12811-42041-1723https://doaj.org/article/a9714ab2ecf84d2fb21b384d6ebd3d762019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12811-4https://doaj.org/toc/2041-1723In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D chromosome organization as a key factor in the NSD2-mediated phenotype.Priscillia LhoumaudSana BadriJavier Rodriguez-HernaezTheodore SakellaropoulosGunjan SethiaAndreas KloetgenMacIntosh CornwellSourya BhattacharyyaFerhat AyRichard BonneauAristotelis TsirigosJane A. SkokNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Priscillia Lhoumaud Sana Badri Javier Rodriguez-Hernaez Theodore Sakellaropoulos Gunjan Sethia Andreas Kloetgen MacIntosh Cornwell Sourya Bhattacharyya Ferhat Ay Richard Bonneau Aristotelis Tsirigos Jane A. Skok NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
description	In multiple myeloma, a 4;14 translocation induces overexpression of histone methyltransferase NSD2, resulting in expansion of H3K36me2 and shrinkage of H3K27me3 domains. Here the authors find that CTCF, H3K27ac and gene expression changes cluster within a subset of insulated domains implicating 3D chromosome organization as a key factor in the NSD2-mediated phenotype.
format	article
author	Priscillia Lhoumaud Sana Badri Javier Rodriguez-Hernaez Theodore Sakellaropoulos Gunjan Sethia Andreas Kloetgen MacIntosh Cornwell Sourya Bhattacharyya Ferhat Ay Richard Bonneau Aristotelis Tsirigos Jane A. Skok
author_facet	Priscillia Lhoumaud Sana Badri Javier Rodriguez-Hernaez Theodore Sakellaropoulos Gunjan Sethia Andreas Kloetgen MacIntosh Cornwell Sourya Bhattacharyya Ferhat Ay Richard Bonneau Aristotelis Tsirigos Jane A. Skok
author_sort	Priscillia Lhoumaud
title	NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
title_short	NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
title_full	NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
title_fullStr	NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
title_full_unstemmed	NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
title_sort	nsd2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/a9714ab2ecf84d2fb21b384d6ebd3d76
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NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

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