Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibito...

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Autores principales:	Yu Muta, Yoshihisa Fujita, Kenta Sumiyama, Atsuro Sakurai, M. Mark Taketo, Tsutomu Chiba, Hiroshi Seno, Kazuhiro Aoki, Michiyuki Matsuda, Masamichi Imajo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a9728e66391f48928bceb937aa59748e
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spelling	oai:doaj.org-article:a9728e66391f48928bceb937aa59748e2021-12-02T14:41:28ZComposite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine10.1038/s41467-018-04527-82041-1723https://doaj.org/article/a9728e66391f48928bceb937aa59748e2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04527-8https://doaj.org/toc/2041-1723The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibitors.Yu MutaYoshihisa FujitaKenta SumiyamaAtsuro SakuraiM. Mark TaketoTsutomu ChibaHiroshi SenoKazuhiro AokiMichiyuki MatsudaMasamichi ImajoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
description	The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibitors.
format	article
author	Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo
author_facet	Yu Muta Yoshihisa Fujita Kenta Sumiyama Atsuro Sakurai M. Mark Taketo Tsutomu Chiba Hiroshi Seno Kazuhiro Aoki Michiyuki Matsuda Masamichi Imajo
author_sort	Yu Muta
title	Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
title_short	Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
title_full	Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
title_fullStr	Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
title_full_unstemmed	Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
title_sort	composite regulation of erk activity dynamics underlying tumour-specific traits in the intestine
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a9728e66391f48928bceb937aa59748e
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Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

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