Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
The ERK signalling pathway regulates homeostasis of the intestinal epithelium. Here the authors identify two modes of ERK activity generated independently from EGFR and ErbB2 receptor and whose balance in cancer is shifted by Wnt pathway activation, resulting in enhanced sensitivity to EGFR inhibito...
Guardado en:
Autores principales: | Yu Muta, Yoshihisa Fujita, Kenta Sumiyama, Atsuro Sakurai, M. Mark Taketo, Tsutomu Chiba, Hiroshi Seno, Kazuhiro Aoki, Michiyuki Matsuda, Masamichi Imajo |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/a9728e66391f48928bceb937aa59748e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation
por: Petrus R. de Jong, et al.
Publicado: (2016) -
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
por: Raphael Brandt, et al.
Publicado: (2019) -
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells
por: D. J. Huels, et al.
Publicado: (2018) -
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
por: Su-Chen Li, et al.
Publicado: (2012) -
Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice
por: Zhenyu Zhong, et al.
Publicado: (2017)